Divergent evolution of CHD3 proteins resulted in MOM1 refining epigenetic control in vascular plants.

PLoS Genetics
Marian CaikovskiJerzy Paszkowski

Abstract

Arabidopsis MOM1 is required for the heritable maintenance of transcriptional gene silencing (TGS). Unlike many other silencing factors, depletion of MOM1 evokes transcription at selected loci without major changes in DNA methylation or histone modification. These loci retain unusual, bivalent chromatin properties, intermediate to both euchromatin and heterochromatin. The structure of MOM1 previously suggested an integral nuclear membrane protein with chromatin-remodeling and actin-binding activities. Unexpected results presented here challenge these presumed MOM1 activities and demonstrate that less than 13% of MOM1 sequence is necessary and sufficient for TGS maintenance. This active sequence encompasses a novel Conserved MOM1 Motif 2 (CMM2). The high conservation suggests that CMM2 has been the subject of strong evolutionary pressure. The replacement of Arabidopsis CMM2 by a poplar motif reveals its functional conservation. Interspecies comparison suggests that MOM1 proteins emerged at the origin of vascular plants through neo-functionalization of the ubiquitous eukaryotic CHD3 chromatin remodeling factors. Interestingly, despite the divergent evolution of CHD3 and MOM1, we observed functional cooperation in epigenetic contr...Continue Reading

References

Dec 1, 1996·Computer Applications in the Biosciences : CABIOS·N GaltierC Gautier
Oct 23, 1997·Proceedings of the National Academy of Sciences of the United States of America·T WoodageF S Collins
Mar 9, 1999·The Plant Journal : for Cell and Molecular Biology·S J Clough, A F Bent
Nov 26, 1999·Proceedings of the National Academy of Sciences of the United States of America·J OgasC Somerville
Jul 19, 2000·The Plant Cell·A SteimerJ Paszkowski
Mar 22, 2001·EMBO Reports·M CokolB Rost
Jan 31, 2002·Current Biology : CB·Doris Wagner, Elliot M Meyerowitz
Jul 26, 2002·Gene·Shahryar KhattakNikolaus A Spoerel
Oct 9, 2002·Proceedings of the National Academy of Sciences of the United States of America·Ortrun Mittelsten ScheidJerzy Paszkowski
Mar 1, 2003·The Plant Journal : for Cell and Molecular Biology·Aline V ProbstOrtrun Mittelsten Scheid
Jun 30, 2004·BMC Evolutionary Biology·Gangolf JobbKorbinian Strimmer
Apr 5, 2005·Nature Structural & Molecular Biology·Nicolas H ThomäNikola P Pavletich
Apr 30, 2005·Nature Reviews. Genetics·Simon W-L ChanSteven E Jacobsen
Aug 16, 2005·Nature·UNKNOWN International Rice Genome Sequencing Project
Jul 6, 2006·Chromosome Research : an International Journal on the Molecular, Supramolecular and Evolutionary Aspects of Chromosome Biology·Karim Bouazoune, Alexander Brehm
Oct 3, 2006·The Plant Journal : for Cell and Molecular Biology·Hidehiro FukakiMasao Tasaka
Nov 4, 2006·EMBO Reports·Yoshiki HabuJerzy Paszkowski
Feb 10, 2007·Cell·Tomoyasu SugiyamaShiv I S Grewal
Sep 26, 2007·The Plant Journal : for Cell and Molecular Biology·Elian PerrucLuis Lopez-Molina

❮ Previous
Next ❯

Citations

May 7, 2014·Proceedings of the National Academy of Sciences of the United States of America·Guillaume MoissiardSteven E Jacobsen
Jun 10, 2014·Proceedings of the National Academy of Sciences of the United States of America·Mayumi Iwasaki, Jerzy Paszkowski
Aug 20, 2009·Acta Crystallographica. Section D, Biological Crystallography·Soheila EmamzadahThanos D Halazonetis
Aug 10, 2010·Acta Crystallographica. Section F, Structural Biology and Crystallization Communications·Tom J PettyStéphane Thore
Feb 22, 2012·PLoS Genetics·Taisuke NishimuraJerzy Paszkowski
May 25, 2011·Biochimica Et Biophysica Acta·Tatsuo Kanno, Yoshiki Habu
Jan 21, 2010·The EMBO Journal·Andrzej T Wierzbicki
Nov 17, 2009·The EMBO Journal·Chotika YokthongwattanaJerzy Paszkowski
Jun 19, 2013·Plant Physiology and Biochemistry : PPB·Yongfeng HuYu Zhao
Sep 22, 2018·The Plant Journal : for Cell and Molecular Biology·Damián A CambiagnoMaría E Alvarez
Jun 30, 2010·Genetika·T V Marenkova, E V Deĭneko

❮ Previous
Next ❯

Methods Mentioned

BETA
transgenic
histone acetylation

Software Mentioned

AtMOM
Seaview
PtMOM
PhyloWin
Treefinder

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.