Divergent expression of regional metabolic topographies in Parkinson's disease and normal ageing

Brain : a Journal of Neurology
J R Moeller, David Eidelberg

Abstract

We have used [18F]fluorodeoxyglucose (FDG) with PET to identify regional metabolic covariance patterns associated with Parkinson's disease and normal ageing. In this study we utilized these patterns as metabolic markers to assess the relative roles of these processes in the progression of parkinsonism. We studied 37 Parkinson's disease patients and 20 normal volunteer subjects with FDG/PET to calculate regional metabolic rates for glucose. We applied the Parkinson's disease and normal ageing regional covariance patterns separately to these data to compute the expression of both these markers in each subject on an individual case basis. The measured expression of the normal ageing pattern provided an estimate of subject age, based entirely upon the FDG/PET data. The normalized difference between this metabolic estimate and chronological age (delta) was then computed, where delta = (metabolic age - real age)/(real age). We found that delta values were negative and significantly reduced in the Parkinson's disease cohort compared with normal subjects (P < 0.005) indicating a consistent underestimation of chronological age by FDG/PET in parkinsonism. In the Parkinson's disease group, delta correlated negatively with disease duration...Continue Reading

Citations

Sep 28, 1998·Annals of Neurology·D EidelbergS Fahn
Dec 5, 2002·Movement Disorders : Official Journal of the Movement Disorder Society·Andrew FeiginDavid Eidelberg
Oct 27, 2004·Journal of Neurology·Kotaro AsanumaDavid Eidelberg
Jun 26, 2004·Current Neurology and Neuroscience Reports·Dennis J Zgaljardic, Andrew Feigin
Nov 24, 1999·Brain Research. Brain Research Reviews·M S NoblerH A Sackeim
Jun 1, 1999·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·A L BrownellO Isacson
Jan 22, 2010·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Chris C TangDavid Eidelberg
May 18, 2005·NeuroRx : the Journal of the American Society for Experimental NeuroTherapeutics·Thomas Eckert, David Eidelberg
Nov 11, 2006·European Journal of Nuclear Medicine and Molecular Imaging·Thomas EckertDavid Eidelberg
Aug 2, 2002·Current Opinion in Neurology·Maren Carbon, David Eidelberg
Feb 13, 2015·Proceedings of the National Academy of Sciences of the United States of America·Phoebe G SpetsierisDavid Eidelberg
Jun 15, 2004·Human Brain Mapping·Catherine LozzaRose-Marie Marié
Dec 31, 2011·NeuroImage·Kathleen L Poston, David Eidelberg
Jan 30, 2010·Parkinsonism & Related Disorders·R B Postuma, J Montplaisir
Jun 4, 2015·Human Brain Mapping·Florian HoltberndCarsten Eggers
Oct 16, 2007·Human Brain Mapping·Adam M BrickmanYaakov Stern
May 22, 2008·Environmental Microbiology·Carlos A Valderrama VasquezPaul D Jepson
Mar 11, 2006·American Journal of Medical Genetics. Part B, Neuropsychiatric Genetics : the Official Publication of the International Society of Psychiatric Genetics·Brad A RacetteJoel S Perlmutter
Sep 4, 2012·Annals of Neurology·Martin Niethammer, David Eidelberg
May 13, 2014·NeuroImage. Clinical·Robert LaforceGil D Rabinovici
Nov 19, 2008·Parkinsonism & Related Disorders·A Jon Stoessl
Nov 18, 2008·Neurobiology of Disease·Kathleen L Poston, David Eidelberg
Nov 11, 2008·NeuroImage·Yilong MaDavid Eidelberg
Mar 29, 2019·Movement Disorders : Official Journal of the Movement Disorder Society·Ronald B Postuma, Daniela Berg
Jan 26, 1999·Movement Disorders : Official Journal of the Movement Disorder Society·C TrenkwalderD Eidelberg
Oct 3, 2020·Frontiers in Aging Neuroscience·Gene E AlexanderTheodore P Trouard
Sep 2, 1998·Current Opinion in Neurology·D Eidelberg
Nov 27, 2019·European Journal of Nuclear Medicine and Molecular Imaging·Sanne K MelesKlaus L Leenders
Oct 17, 2018·Seminars in Nuclear Medicine·Baijayanta Maiti, Joel S Perlmutter

❮ Previous
Next ❯

Related Concepts

Related Feeds

Aging-Associated Metabolic Disorders

Age is associated with many metabolic disorders including cardiovascular diseases, type 2 diabetes, stroke and heart disease. The mediators in aging process have been suggested to play a part in the cellular processes responsible for these metabolic disorders. Here is the latest research on aging-associated metabolic disorders.

Cell Aging (Keystone)

This feed focuses on cellular aging with emphasis on the mitochondria, autophagy, and metabolic processes associated with aging and longevity. Here is the latest research on cell aging.

Cell Aging

This feed focuses on cellular aging with emphasis on mitochondria, autophagy, and metabolic processes associated with aging and longevity. Here is the latest research on cell aging.

Brain Aging

Here is the latest research on intrinsic and extrinsic factors, as well as pathways and mechanisms that underlie aging in the central nervous system.

Related Papers

Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism
Yilong MaDavid Eidelberg
Movement Disorders : Official Journal of the Movement Disorder Society
Andrew FeiginDavid Eidelberg
Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism
David EidelbergS Przedborski
© 2021 Meta ULC. All rights reserved