Divergent fibroblast growth factor signaling pathways in lung fibroblast subsets: where do we go from here?

American Journal of Physiology. Lung Cellular and Molecular Physiology
Jordi Ruiz-Camp, Rory E Morty

Abstract

Lung fibroblasts play a key role in postnatal lung development, namely, the formation of the alveolar gas exchange units, through the process of secondary septation. Although evidence initially highlighted roles for fibroblasts in the production and remodeling of the lung extracellular matrix, more recent studies have described the presence of different fibroblast subsets in the developing lung. These subsets include myofibroblasts and lipofibroblasts and their precursors. These cells are believed to play different roles in alveologenesis and are localized to different regions of the developing septa. The precise roles played by these different fibroblast subsets remain unclear. Understanding the signaling pathways that control the discrete functions of these fibroblast subsets would help to clarify the roles and the regulation of lung fibroblasts during lung development. Here, we critically evaluate a recent report that described divergent fibroblast growth factor (FGF) signaling pathways in two different subsets of lung fibroblasts that express different levels of green fluorescent protein (GFP) driven by the platelet-derived growth factor receptor-α promoter. The GFP expression was used as a surrogate for lipofibroblasts (GF...Continue Reading

References

Dec 1, 1978·The Anatomical Record·C Vaccaro, J S Brody
Jan 23, 1999·Nature Genetics·K SekineS Kato
Oct 16, 1999·Proceedings of the National Academy of Sciences of the United States of America·E ArmanP Lonai
Jan 23, 2002·Developmental Dynamics : an Official Publication of the American Association of Anatomists·Hans BoströmChrister Betsholtz
Sep 1, 2004·Biochemical and Biophysical Research Communications·Hiroko UsuiNobuyuki Itoh
Sep 28, 2004·American Journal of Physiology. Lung Cellular and Molecular Physiology·Bernadette Chailley-HeuJacques R Bourbon
May 3, 2005·Cytokine & Growth Factor Reviews·V P EswarakumarJ Schlessinger
Jun 13, 2006·American Journal of Physiology. Lung Cellular and Molecular Physiology·Carlos RamosMoisés Selman
Oct 31, 2006·American Journal of Physiology. Lung Cellular and Molecular Physiology·John T BenjaminLawrence S Prince
Nov 9, 2006·Experimental Lung Research·Virender K RehanJohn S Torday
Oct 4, 2008·The Anatomical Record : Advances in Integrative Anatomy and Evolutionary Biology·Stephen E McGowanAmey J Holmes
Jun 9, 2009·American Journal of Physiology. Lung Cellular and Molecular Physiology·Anne-Karina T Perl, Emily Gale
Jan 23, 2010·American Journal of Respiratory and Critical Care Medicine·Sorachai SrisumaThomas J Mariani
Feb 16, 2010·Developmental Cell·Edward E Morrisey, Brigid L M Hogan
May 25, 2010·American Journal of Physiology. Lung Cellular and Molecular Physiology·Carlos RamosMoisés Selman
Jun 11, 2011·Pediatric Research·Stephen E McGowan, Diann M McCoy
Sep 1, 2011·Physiological Genomics·Marie-Laure Franco-MontoyaJacques R Bourbon
Apr 16, 2013·American Journal of Physiology. Lung Cellular and Molecular Physiology·Jacob KachNickolai O Dulin
Apr 24, 2013·Annals of the American Thoracic Society·Edward E MorriseyQing S Lin
Jun 12, 2013·American Journal of Physiology. Lung Cellular and Molecular Physiology·Stephen E McGowan, Diann M McCoy
Aug 13, 2013·American Journal of Physiology. Lung Cellular and Molecular Physiology·Patricia R BachillerJesse D Roberts
Nov 12, 2013·American Journal of Physiology. Lung Cellular and Molecular Physiology·Alicia MadurgaRory E Morty
Jan 1, 2014·American Journal of Physiology. Lung Cellular and Molecular Physiology·Jute RichterJan Deprest
Jan 1, 2014·American Journal of Physiology. Lung Cellular and Molecular Physiology·Shilpa Vyas-ReadLou Ann S Brown
Jan 21, 2014·American Journal of Physiology. Lung Cellular and Molecular Physiology·Luai HuleihelNaftali Kaminski
Jan 23, 2014·Development·Michael Herriges, Edward E Morrisey
Mar 19, 2014·Birth Defects Research. Part A, Clinical and Molecular Teratology·Stephen E McGowan
Jun 8, 2014·American Journal of Physiology. Lung Cellular and Molecular Physiology·Antonia P PopovaMarc B Hershenson
Jun 29, 2014·American Journal of Physiology. Lung Cellular and Molecular Physiology·Daniel TahedlChristian Mühlfeld
Aug 26, 2014·American Journal of Physiology. Lung Cellular and Molecular Physiology·Stephen E McGowan, Diann M McCoy
Sep 7, 2014·American Journal of Physiology. Lung Cellular and Molecular Physiology·Katrin Ahlbrecht, Stephen E McGowan
Oct 5, 2014·American Journal of Physiology. Lung Cellular and Molecular Physiology·Bradley A Yoder, Jacqueline J Coalson
Oct 12, 2014·American Journal of Physiology. Lung Cellular and Molecular Physiology·Methap YurtVirender K Rehan
Oct 12, 2014·American Journal of Physiology. Lung Cellular and Molecular Physiology·Megan O'Reilly, Bernard Thébaud
Oct 12, 2014·American Journal of Physiology. Lung Cellular and Molecular Physiology·Jessica Berger, Vineet Bhandari
Oct 19, 2014·American Journal of Physiology. Lung Cellular and Molecular Physiology·Carl T D'Angio, Rita M Ryan
Dec 4, 2014·Developmental Dynamics : an Official Publication of the American Association of Anatomists·Thomas Volckaert, Stijn P De Langhe
Jul 4, 2015·American Journal of Physiology. Lung Cellular and Molecular Physiology·Stephen E McGowan, Diann M McCoy

❮ Previous
Next ❯

Citations

Jun 29, 2018·American Journal of Physiology. Lung Cellular and Molecular Physiology·Katharina HeinzelmannOliver Eickelberg
May 31, 2019·Journal of Cellular Biochemistry·Hua-Shu YuanHui Luo
Nov 15, 2015·American Journal of Physiology. Lung Cellular and Molecular Physiology·Eun Jun YunThiennu H Vu
Aug 8, 2018·Respiratory Research·José Alberto Rodríguez-CastilloKatrin Ahlbrecht
May 17, 2018·Stem Cells International·Judith GronbachHarald Ehrhardt
Dec 6, 2016·Cell and Tissue Research·Claudio NardielloRory E Morty
Feb 17, 2019·International Journal of Molecular Sciences·Zuzana NovaAndrea Calkovska
Oct 4, 2017·American Journal of Physiology. Lung Cellular and Molecular Physiology·David E Surate SolaligueRory E Morty
Feb 6, 2020·Respiratory Research·Guillaume LezmiChristophe Delacourt
Jul 21, 2020·Annals of Anatomy = Anatomischer Anzeiger : Official Organ of the Anatomische Gesellschaft·Sophie FeddersenRory E Morty

❮ Previous
Next ❯

Related Concepts

Related Feeds

Cell Migration

Cell migration is involved in a variety of physiological and pathological processes such as embryonic development, cancer metastasis, blood vessel formation and remoulding, tissue regeneration, immune surveillance and inflammation. Here is the latest research.

Related Papers

Birth Defects Research. Part C, Embryo Today : Reviews
Namjin Kim, Thiennu H Vu
American Journal of Physiology. Lung Cellular and Molecular Physiology
Stephen E McGowan, Diann M McCoy
American Journal of Physiology. Lung Cellular and Molecular Physiology
Stephen E McGowan, Diann M McCoy
© 2021 Meta ULC. All rights reserved