Divergent Influences of Cardiovascular Disease Risk Factor Domains on Cognition and Gray and White Matter Morphology

Psychosomatic Medicine
Mitzi M GonzalesMelissa Lamar

Abstract

Hypertension, diabetes, dyslipidemia, and obesity are associated with preclinical alterations in cognition and brain structure; however, this often comes from studies of comprehensive risk scores or single isolated factors. We examined associations of empirically derived cardiovascular disease risk factor domains with cognition and brain structure. A total of 124 adults (age, 59.8 [13.1] years; 41% African American; 50% women) underwent neuropsychological and cardiovascular assessments and structural magnetic resonance imaging. Principal component analysis of nine cardiovascular disease risk factors resulted in a four-component solution representing 1, cholesterol; 2, glucose dysregulation; 3, metabolic dysregulation; and 4, blood pressure. Separate linear regression models for learning, memory, executive functioning, and attention/information processing were performed, with all components entered at once, adjusting for age, sex, and education. MRI analyses included whole-brain cortical thickness and tract-based fractional anisotropy adjusted for age and sex. Higher blood pressure was associated with poorer learning (B = -0.19; p = .019), memory (B = -0.22; p = .005), and executive functioning performance (B = -0.14; p = .031),...Continue Reading

References

Nov 1, 1975·Journal of Psychiatric Research·M F FolsteinP R McHugh
Sep 14, 2000·Proceedings of the National Academy of Sciences of the United States of America·B Fischl, A M Dale
Mar 22, 2001·Nature·M EkA Ericsson-Dahlstrand
May 23, 2001·JAMA : the Journal of the American Medical Association·UNKNOWN Expert Panel on Detection, Evaluation, and Treatment of High Blood Cholesterol in Adults
Apr 18, 2002·Proceedings of the National Academy of Sciences of the United States of America·Michael PetridesStephen Frey
Jan 12, 2005·Behavior Research Methods, Instruments, & Computers : a Journal of the Psychonomic Society, Inc·Kristopher J Preacher, Andrew F Hayes
Feb 4, 2005·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·Sean C L DeoniBrian K Rutt
Oct 15, 2005·Neurobiology of Aging·Merrill F EliasRalph B D'Agostino
Jan 6, 2006·Journal of Personality and Social Psychology·Dominique MullerVincent Y Yzerbyt
Apr 21, 2006·NeuroImage·Stephen M SmithTimothy E J Behrens
Apr 20, 2007·Neuropathology and Applied Neurobiology·J E SimpsonUNKNOWN MRC Cognitive Function and Ageing Neuropathology Study Group
May 19, 2007·Stroke; a Journal of Cerebral Circulation·Lori L Beason-HeldSusan M Resnick
Oct 5, 2007·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Eugene D PonomarevBonnie N Dittel
Sep 19, 2008·Acta Neurologica Scandinavica·K HannesdottirH S Markus
Jul 3, 2009·Current Opinion in Neurology·Susumu MoriAndreia V Faria
Sep 29, 2009·Population Health Metrics·Goodarz DanaeiMajid Ezzati
Dec 19, 2009·Circulation·UNKNOWN WRITING GROUP MEMBERSUNKNOWN American Heart Association Statistics Committee and Stroke Statistics Subcommittee
Jan 29, 2010·Diabetes Care·UNKNOWN American Diabetes Association
Jul 2, 2011·Acta Diabetologica·Eiji Oda
Aug 21, 2012·Neurobiology of Aging·Miika VuorinenAlina Solomon
Sep 11, 2012·Diabetes Care·Yael D ReijmerUNKNOWN Utrecht Vascular Cognitive Impairment Study Group
Oct 2, 2013·The American Journal of Geriatric Psychiatry : Official Journal of the American Association for Geriatric Psychiatry·Melissa LamarSean C Deoni
Jul 7, 2014·Neurobiology of Aging·Nicholus M WarstadtUNKNOWN Alzheimer's Disease Neuroimaging Initiative (ADNI)
Jan 13, 2015·Stroke; a Journal of Cerebral Circulation·Anil M TuladharFrank-Erik de Leeuw
Jun 23, 2015·Psychosomatic Medicine·Sonya KaurAndreana P Haley

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Citations

Nov 7, 2019·Stress and Health : Journal of the International Society for the Investigation of Stress·Moïse-Denis K JeanOlusola A Ajilore
Aug 25, 2020·Psychophysiology·J Richard JenningsPeter J Gianaros
May 23, 2020·Neuroscience and Biobehavioral Reviews·Laura W M VergoossenMiranda T Schram
Jan 26, 2021·Acta Psychiatrica Scandinavica·Kody G KennedyBenjamin I Goldstein

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