Divergent prolactin and pituitary-adrenal activity in rats selectively bred for different dopamine responsiveness

Endocrinology
N Y RotsE R de Kloet

Abstract

The present study explores the significance of brain dopamine phenotype for individual variation in the neuroendocrine stress response of the rat. For this purpose, we used two Wistar rat lines previously selected for high or low responsiveness of the dopamine system to apomorphine using the gnawing response as the selection criterion. Systemic administration of the drug evoked in apomorphine-susceptible (apo-sus) rats a vigorous gnawing response, whereas apomorphine-unsusceptible (apo-unsus) rats did not gnaw under these conditions. These two rat lines represent individuals displaying extreme differences in gnawing behavior that otherwise coexist in a normal Wistar population. In this study basal and stress-induced hypothalamic-pituitary-adrenal activity and PRL release were measured in chronically cannulated, freely moving rats that endured a conditioned emotional response. Tyrosine hydroxylase messenger RNA (mRNA), corticosteroid receptor mRNA, and in vivo retention of [3H]corticosterone were measured in rat brain sections using in situ hybridization and in vivo autoradiography. The result show that 1) apo-sus rats had a markedly reduced PRL response to stress compared to apo-unsus animals, whereas basal levels were not sign...Continue Reading

Citations

Jun 1, 1996·Cellular and Molecular Neurobiology·E R de KloetA R Cools
Oct 2, 2007·Physiology & Behavior·P J F MartinsV D'Almeida
Jul 9, 2004·Annals of the New York Academy of Sciences·Alexa H VeenemaE Ronald de Kloet
Nov 3, 2010·Physiology & Behavior·Jessica E van SchijndelGerard J M Martens
Jun 1, 1997·Gynecological Endocrinology : the Official Journal of the International Society of Gynecological Endocrinology·M MoroF Cavagnini
Aug 18, 2006·Behavioural Pharmacology·Elizabeth L van der KamAlexander R Cools
Aug 1, 2002·Acta Neuropsychiatrica·Er de Kloet
Mar 1, 1999·Acta Neuropsychiatrica·S Tuinier, W M Verhoeven
Sep 24, 2010·Endocrinology·Ratna A SarabdjitsinghStafford L Lightman
Jun 17, 1998·Endocrine Reviews·E R De KloetM Joëls
Oct 27, 1998·Stress : the International Journal on the Biology of Stress·D L HelmreichS J Watson

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