Divergent roles of growth factors in the GnRH regulation of puberty in mice.

The Journal of Clinical Investigation
Sara A DiVallAndrew Wolfe

Abstract

Pubertal onset, initiated by pulsatile gonadotropin-releasing hormone (GnRH), only occurs in a favorable, anabolic hormonal milieu. Anabolic factors that may signal nutritional status to the hypothalamus include the growth factors insulin and IGF-1. It is unclear which hypothalamic neuronal subpopulation these factors affect to ultimately regulate GnRH neuron function in puberty and reproduction. We examined the direct role of the GnRH neuron in growth factor regulation of reproduction using the Cre/lox system. Mice with the IR or IGF-1R deleted specifically in GnRH neurons were generated. Male and female mice with the IR deleted in GnRH neurons displayed normal pubertal timing and fertility, but male and female mice with the IGF-1R deleted in GnRH neurons experienced delayed pubertal development with normal fertility. With IGF-1 administration, puberty was advanced in control females, but not in females with the IGF-1R deleted in GnRH neurons, in control males, or in knockout males. These mice exhibited developmental differences in GnRH neuronal morphology but normal number and distribution of neurons. These studies define the role of IGF-1R signaling in the coordination of somatic development with reproductive maturation and ...Continue Reading

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Citations

Feb 23, 2013·Cell and Tissue Research·Miriam Schneider
Dec 14, 2011·Molecular Neurobiology·Sheng Wu, Andrew Wolfe
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Methods Mentioned

BETA
PCR
lavage
sedation
dissection
Assay

Software Mentioned

GraphPad
GraphPad Prism
xPonent
Axiovision

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