Divergent selection on locally adapted major histocompatibility complex immune genes experimentally proven in the field.

Ecology Letters
Christophe EizaguirreM Milinski

Abstract

Although crucial for the understanding of adaptive evolution, genetically resolved examples of local adaptation are rare. To maximize survival and reproduction in their local environment, hosts should resist their local parasites and pathogens. The major histocompatibility complex (MHC) with its key function in parasite resistance represents an ideal candidate to investigate parasite-mediated local adaptation. Using replicated field mesocosms, stocked with second-generation lab-bred three-spined stickleback hybrids of a lake and a river population, we show local adaptation of MHC genotypes to population-specific parasites, independently of the genetic background. Increased allele divergence of lake MHC genotypes allows lake fish to fight the broad range of lake parasites, whereas more specific river genotypes confer selective advantages against the less diverse river parasites. Hybrids with local MHC genotype gained more body weight and thus higher fitness than those with foreign MHC in either habitat, suggesting the evolutionary significance of locally adapted MHC genotypes.

References

Jan 1, 1990·Immunologic Research·E K WakelandW K Potts
Jun 23, 2000·Nature·C M Lively, M F Dybdahl
Jul 30, 2002·Evolution; International Journal of Organic Evolution·Andrew P HendryJ Donald McPhail
Nov 27, 2002·Evolution; International Journal of Organic Evolution·Philip W Hedrick
Nov 26, 2003·Journal of Evolutionary Biology·L Bernatchez, C Landry
Nov 26, 2003·Journal of Evolutionary Biology·K M WegnerM Kalbe
Jun 2, 2005·Evolution; International Journal of Organic Evolution·Patrik NosilDaniel J Funk
Jul 11, 2006·Science·Hopi E HoekstraJanet P Crossland
Nov 23, 2006·Trends in Ecology & Evolution·Jon R Bridle, Timothy H Vines
Jan 26, 2007·Proceedings. Biological Sciences·Elvira de EytoRené J M Stet
Mar 30, 2007·Molecular Ecology·Robert EkblomJacob Höglund
May 15, 2007·Ecology Letters·Megan A Greischar, Britt Koskella
Aug 30, 2008·Science·Rowan D H BarrettDolph Schluter
Nov 27, 2008·Proceedings. Biological Sciences·Martin KalbeManfred Milinski
Dec 18, 2008·Ecology Letters·Christophe EizaguirreManfred Milinski
Feb 21, 2009·Evolution; International Journal of Organic Evolution·Daniel BernerAndrew P Hendry
Mar 11, 2009·The American Naturalist·Joe Hereford
Sep 4, 2009·Genetica·Bonnie A Fraser, Bryan D Neff
Jan 15, 2010·Proceedings. Biological Sciences·Lewis G Spurgin, David S Richardson
Oct 15, 2010·Proceedings. Biological Sciences·Claire LoiseauGabriele Sorci
Mar 8, 2011·Ecology Letters·Martine E Maan, Ole Seehausen
Jan 12, 2012·Nature Communications·Christophe EizaguirreManfred Milinski

❮ Previous
Next ❯

Citations

Nov 2, 2013·Fish & Shellfish Immunology·Frederik FrankeJörn P Scharsack
Oct 23, 2013·Trends in Parasitology·Iain Barber
May 31, 2013·Proceedings. Biological Sciences·Victor A StiebensChristophe Eizaguirre
Mar 3, 2015·Molecular Ecology·Linda A WhittinghamPeter O Dunn
Jul 30, 2015·Evolution; International Journal of Organic Evolution·Gregor RolshausenAndrew P Hendry
Aug 11, 2015·Molecular Ecology·Brent W Young, Matthew D Dean
May 6, 2015·Methods in Ecology and Evolution·Carolina Pardo-DiazChris D Jiggins
Apr 15, 2016·PeerJ·Miguel Baltazar-SoaresChristophe Eizaguirre
May 24, 2016·Zoology : Analysis of Complex Systems, ZACS·Franziska S Brunner, Christophe Eizaguirre
Jun 13, 2016·Zoology : Analysis of Complex Systems, ZACS·Jörn P ScharsackMartin Kalbe
Aug 24, 2016·Ecology and Evolution·Miguel Baltazar-Soares, Christophe Eizaguirre
Jul 14, 2016·Molecular Ecology·Catalina Gonzalez-QuevedoDavid S Richardson
Aug 12, 2016·Proceedings. Biological Sciences·Aliya El Nagar, Andrew D C MacColl
Aug 24, 2016·Integrative and Comparative Biology·Brian Hoover, Gabrielle Nevitt
Aug 23, 2016·Nature Genetics·Martin MalmstrømSissel Jentoft
Nov 20, 2016·Journal of Evolutionary Biology·D BernerD Moser
Feb 24, 2017·Evolution; International Journal of Organic Evolution·Yann BourgeoisDieter Ebert
Feb 15, 2017·Scientific Reports·Shaun RobertsonAndrew D C MacColl
Jan 18, 2018·Proceedings of the National Academy of Sciences of the United States of America·Karl P PhillipsJacek Radwan
Mar 27, 2018·Journal of Evolutionary Biology·Tiago H S PiresIzeni P Farias
Apr 15, 2018·Molecular Ecology·Aleksandra BiedrzyckaJacek Radwan
Jul 21, 2017·Molecular Ecology·Brian K LohmanDaniel I Bolnick
Jun 27, 2018·Journal of Evolutionary Biology·Anssi KarvonenOle Seehausen

❮ Previous
Next ❯

Methods Mentioned

BETA
PCR
dissections
dissection

Software Mentioned

ANOSIM
R Development Core Team
R
Primer

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.