Divergent Total Syntheses of Rhodomyrtosones A and B

The Journal of Organic Chemistry
Anais GervaisJohn A Porco

Abstract

Herein, we report total syntheses of the tetramethyldihydroxanthene natural product rhodomyrtosone B and the related bis-furan β-triketone natural product rhodomyrtosone A. Nickel-(II)-catalyzed 1,4-conjugate addition of an α-alkylidene-β-dicarbonyl substrate was developed to access the congener rhodomyrtosone B, and oxygenation of the same monoalkylidene derivative followed by cyclization was employed to obtain the bis-furan natural product rhodomyrtosone A.

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Citations

Dec 24, 2018·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Rosario NicolettiAnna Andolfi
Apr 17, 2018·Organic Letters·Yonghong GuoZhixiang Xie

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