Diverging volumetric trajectories following pediatric traumatic brain injury

NeuroImage. Clinical
Emily L DennisRobert F Asarnow

Abstract

Traumatic brain injury (TBI) is a significant public health concern, and can be especially disruptive in children, derailing on-going neuronal maturation in periods critical for cognitive development. There is considerable heterogeneity in post-injury outcomes, only partially explained by injury severity. Understanding the time course of recovery, and what factors may delay or promote recovery, will aid clinicians in decision-making and provide avenues for future mechanism-based therapeutics. We examined regional changes in brain volume in a pediatric/adolescent moderate-severe TBI (msTBI) cohort, assessed at two time points. Children were first assessed 2-5 months post-injury, and again 12 months later. We used tensor-based morphometry (TBM) to localize longitudinal volume expansion and reduction. We studied 21 msTBI patients (5 F, 8-18 years old) and 26 well-matched healthy control children, also assessed twice over the same interval. In a prior paper, we identified a subgroup of msTBI patients, based on interhemispheric transfer time (IHTT), with significant structural disruption of the white matter (WM) at 2-5 months post injury. We investigated how this subgroup (TBI-slow, N = 11) differed in longitudinal regional volume c...Continue Reading

Citations

Mar 1, 2018·The Neuroscientist : a Review Journal Bringing Neurobiology, Neurology and Psychiatry·Emily L DennisRobert F Asarnow
May 10, 2019·Frontiers in Neurology·Zoe M TappOlga N Kokiko-Cochran
Mar 5, 2019·Nursing Research·Kaylee C SchnurKarin Reuter-Rice
May 23, 2018·Journal of Abnormal Child Psychology·Kathryn L HumphreysIan H Gotlib
May 6, 2019·Experimental Neurology·Naomi S Sta MariaChristopher C Giza
Sep 6, 2020·American Journal of Physical Medicine & Rehabilitation·Eunkyung KimByung-Mo Oh

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