Diverse autonomic regulation of pupillary function and the cardiovascular system during alcohol withdrawal

Drug and Alcohol Dependence
Thomas JochumKarl-Jürgen Bär

Abstract

Previous research indicated the complexity of autonomic dysfunction during acute alcohol withdrawal. This study aimed to investigate the pupillary light reflex as an indicator of midbrain and brainstem regulatory systems in relation to cardiovascular autonomic function. Thirty male patients were included in the study. They were investigated during acute alcohol withdrawal syndrome and 24h later during clomethiazole treatment and compared to healthy controls. Parameters of pupillary light reflex of both eyes as well as heart rate variability, blood pressure variability and baroreflex sensitivity (BRS) were studied. We observed significantly reduced sympathetic (small diameter, e.g., left eye: 5.00 in patients vs. 5.91mm in controls) and vagal modulation (e.g., prolonged latencies, left eye: 0.28 vs. 0.26ms) regarding both pupils during acute alcohol withdrawal syndrome. Cardiovascular parameters showed reduced vagal modulation (e.g., b-slope of BRS: 7. 57 vs. 13.59ms/mm Hg) and mixed results for sympathetic influence. After 24h, autonomic dysfunction improved significantly, both for the pupils (e.g., left diameter: 5.38mm) and the heart (e.g., b-slope of BRS: 9.34ms/mm Hg). While parameters obtained from the pupil correlated wit...Continue Reading

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Citations

Mar 14, 2018·Diagnostics·Charlotte A Hall, Robert P Chilcott
Jan 5, 2020·Clinical Autonomic Research : Official Journal of the Clinical Autonomic Research Society·Vanessa Troiani
Mar 29, 2019·Frontiers in Psychiatry·Marco HerbslebBerend Malchow
Apr 8, 2021·Journal of Biomedical Informatics·Hedenir Monteiro Pinheiro, Ronaldo Martins da Costa

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