Diverse bacterial PKS sequences derived from okadaic acid-producing dinoflagellates.

Marine Drugs
Roberto PerezKathleen S Rein

Abstract

Okadaic acid (OA) and the related dinophysistoxins are isolated from dinoflagellates of the genus Prorocentrum and Dinophysis. Bacteria of the Roseobacter group have been associated with okadaic acid producing dinoflagellates and have been previously implicated in OA production. Analysis of 16S rRNA libraries reveals that Roseobacter are the most abundant bacteria associated with OA producing dinoflagellates of the genus Prorocentrum and are not found in association with non-toxic dinoflagellates. While some polyketide synthase (PKS) genes form a highly supported Prorocentrum clade, most appear to be bacterial, but unrelated to Roseobacter or Alpha-Proteobacterial PKSs or those derived from other Alveolates Karenia brevis or Crytosporidium parvum.

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Citations

Jun 14, 2014·PloS One·Amy E KoidKarla B Heidelberg
Nov 22, 2012·Marine Drugs·Tamara S VilchesJosé J Fernández
Apr 17, 2009·Marine Drugs·Alejandro M S Mayer
Apr 23, 2010·Marine Drugs·Schonna R Manning, John W La Claire
Apr 23, 2010·Marine Drugs·Ivan Vilotijevic, Timothy F Jamison
May 19, 2010·Marine Drugs·Ralf KellmannKjetill S Jakobsen
Sep 19, 2009·Toxicon : Official Journal of the International Society on Toxinology·John A KalaitzisBrett A Neilan
Sep 9, 2009·Toxicon : Official Journal of the International Society on Toxinology·Tianying AnKathleen S Rein
Aug 14, 2012·Biotechnology Advances·J Gallardo-RodríguezE Molina-Grima
May 11, 2016·Marine Environmental Research·G RomanoA Ianora

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Datasets Mentioned

BETA
AAX51692
AY851763
AAO64407.1
AAX51693.1
CAM74077.1
AAM30566.1
AAT43773.1

Methods Mentioned

BETA
ELISA
PCR
electrophoresis

Software Mentioned

BLASTP
PAUP
MODELTEST
BLASTN
CLUSTALX
DNA Star
MegAlign
BLASTX
SeqMan

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