Diverse clinical and histology presentation in c1q nephropathy

Nephro-urology Monthly
Pavan Malleshappa, Mahesha Vankalakunti

Abstract

Patients presenting with nephrotic syndrome with or without nephritic illness rarely come across with the diagnosis of 'C1q nephropathy'. This entity is purely diagnosed with the help of immunofluorescence like IgA nephropathy. Clinical presentation is heterogenous, ranging from nephrotic range proteinuria to sub-nephrotic state; and with or without hematuria / renal insufficiency. Similarly, the concept of 'C1q nephroapthy' has periodically evolved since its original description by Jenette and Hipp in 1985. Here the pathophysiology, histologic findings / diagnostic and therapeutic options in patients with C1q nephropathy are discussed.

References

Oct 1, 1991·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·S S IskandarW B Lorentz
Aug 1, 1985·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·J C Jennette, C G Hipp
May 4, 2000·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·M NishidaT Sawada
Sep 7, 2000·Pediatric Nephrology : Journal of the International Pediatric Nephrology Association·T SrivastavaU S Alon
Sep 13, 2003·Kidney International·Glen S MarkowitzVivette D D'Agati
Oct 6, 2005·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Stefan P BergerMohamed R Daha
Oct 26, 2005·Pediatric Nephrology : Journal of the International Pediatric Nephrology Association·Tanja Kersnik LevartAlenka Vizjak
Apr 26, 2007·Nature Clinical Practice. Nephrology·Katherine M BrownNeil S Sheerin
Nov 6, 2007·Journal of Korean Medical Science·In Seok LimHae Il Cheong
Jul 25, 2008·Clinical Journal of the American Society of Nephrology : CJASN·Satoshi HisanoHiroshi Iwasaki
Jul 25, 2008·Journal of the American Society of Nephrology : JASN·Alenka VizjakJ Charles Jennette
Feb 7, 2009·Archives of Pathology & Laboratory Medicine·David B Thomas
Apr 18, 2009·Clinical and Experimental Nephrology·Akiko MiiYuh Fukuda
May 18, 2010·Modern Pathology : an Official Journal of the United States and Canadian Academy of Pathology, Inc·Samar M SaidSamih H Nasr
Nov 26, 2010·Clinical and Experimental Nephrology·Aditi SinhaStanley C Jordan

❮ Previous
Next ❯

Citations

Feb 21, 2018·Arkhiv patologii·V A VarshavskyE I Gudkova

❮ Previous
Next ❯

Methods Mentioned

BETA
electron microscopy
biopsies
light microscopy
biopsy

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Hereditary Sensory Autonomic Neuropathy

Hereditary Sensory Autonomic Neuropathies are a group of inherited neurodegenerative disorders characterized clinically by loss of sensation and autonomic dysfunction. Here is the latest research on these neuropathies.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Landau-Kleffner Syndrome

Landau Kleffner syndrome (LKS), also called infantile acquired aphasia, acquired epileptic aphasia, or aphasia with convulsive disorder, is a rare childhood neurological syndrome characterized by the sudden or gradual development of aphasia (the inability to understand or express language) and an abnormal electroencephalogram. Discover the latest research on LKS here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Regulation of Vocal-Motor Plasticity

Dopaminergic projections to the basal ganglia and nucleus accumbens shape the learning and plasticity of motivated behaviors across species including the regulation of vocal-motor plasticity and performance in songbirds. Discover the latest research on the regulation of vocal-motor plasticity here.