Diverse definitions of the early course of schizophrenia-a targeted literature review

NPJ Schizophrenia
Richard NewtonBenedicto Crespo-Facorro

Abstract

Schizophrenia is a debilitating psychiatric disorder and patients experience significant comorbidity, especially cognitive and psychosocial deficits, already at the onset of disease. Previous research suggests that treatment during the earlier stages of disease reduces disease burden, and that a longer time of untreated psychosis has a negative impact on treatment outcomes. A targeted literature review was conducted to gain insight into the definitions currently used to describe patients with a recent diagnosis of schizophrenia in the early course of disease ('early' schizophrenia). A total of 483 relevant English-language publications of clinical guidelines and studies were identified for inclusion after searches of MEDLINE, MEDLINE In-Process, relevant clinical trial databases and Google for records published between January 2005 and October 2015. The extracted data revealed a wide variety of terminology and definitions used to describe patients with 'early' or 'recent-onset' schizophrenia, with no apparent consensus. The most commonly used criteria to define patients with early schizophrenia included experience of their first episode of schizophrenia or disease duration of less than 1, 2 or 5 years. These varied definitions ...Continue Reading

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Citations

Oct 19, 2019·The American Journal of Psychiatry·Maureen McHugoStephan Heckers
Jan 30, 2020·Zhurnal nevrologii i psikhiatrii imeni S.S. Korsakova·D V IvashchenkoD A Sychev
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Sep 3, 2020·Translational Psychiatry·Maureen McHugoStephan Heckers
Oct 24, 2020·Current Medical Research and Opinion·Benedicto Crespo-FacorroRichard Newton
Jan 15, 2021·Early Intervention in Psychiatry·Emmanuel K MwesigaDan J Stein
Jan 20, 2021·PloS One·Valentina PrestaGiuliana Gobbi
Dec 3, 2020·Neuropsychiatric Disease and Treatment·Wenying YiYuping Ning
Mar 19, 2021·Revista colombiana de psiquiatría·Juan F CanoJairo González-Díaz
Apr 21, 2021·Psychological Medicine·Maureen McHugoStephan Heckers
May 11, 2021·European Psychiatry : the Journal of the Association of European Psychiatrists·Isabella CostamagnaRobert Goldman
Sep 3, 2021·Psychiatric Services : a Journal of the American Psychiatric Association·Jessica A WojtalikShaun M Eack

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