Diverse definitions of the early course of schizophrenia-a targeted literature review

NPJ Schizophrenia
Richard NewtonBenedicto Crespo-Facorro


Schizophrenia is a debilitating psychiatric disorder and patients experience significant comorbidity, especially cognitive and psychosocial deficits, already at the onset of disease. Previous research suggests that treatment during the earlier stages of disease reduces disease burden, and that a longer time of untreated psychosis has a negative impact on treatment outcomes. A targeted literature review was conducted to gain insight into the definitions currently used to describe patients with a recent diagnosis of schizophrenia in the early course of disease ('early' schizophrenia). A total of 483 relevant English-language publications of clinical guidelines and studies were identified for inclusion after searches of MEDLINE, MEDLINE In-Process, relevant clinical trial databases and Google for records published between January 2005 and October 2015. The extracted data revealed a wide variety of terminology and definitions used to describe patients with 'early' or 'recent-onset' schizophrenia, with no apparent consensus. The most commonly used criteria to define patients with early schizophrenia included experience of their first episode of schizophrenia or disease duration of less than 1, 2 or 5 years. These varied definitions ...Continue Reading


Sep 1, 1992·The American Journal of Psychiatry·A D LoebelS R Szymanski
Mar 30, 2000·The American Journal of Psychiatry·R M BilderJ A Lieberman
Mar 19, 2005·Journal of Neurology, Neurosurgery, and Psychiatry·G PriceM A Ron
Jul 12, 2005·Schizophrenia Bulletin·Delbert G RobinsonJohn M Kane
Aug 2, 2005·Psychiatry Research·Thomas J WhitfordLeanne M Williams
Aug 2, 2005·The American Journal of Psychiatry·Jay NierenbergMartha E Shenton
Aug 2, 2005·The British Journal of Psychiatry. Supplement·Matcheri S KeshavanChristos Pantelis
Dec 2, 2005·The British Journal of Psychiatry : the Journal of Mental Science·Katarzyna Kucharska-PieturaMary L Phillips
Mar 1, 2006·Schizophrenia Research·Tsutomu TakahashiMasayoshi Kurachi
Jun 9, 2006·Progress in Neuro-psychopharmacology & Biological Psychiatry·Hitoshi TakahashiHisashi Higuchi
May 15, 2007·Neuroreport·Thomas J WhitfordLeanne M Williams
Aug 28, 2007·The Psychiatric Clinics of North America·Peter J WeidenMichael Grody
Nov 15, 2007·European Archives of Psychiatry and Clinical Neuroscience·Müge Devrim-UçokAlp Uçok
Dec 8, 2007·Comprehensive Psychiatry·John P JohnMohan K Isaac
May 2, 2008·Psychological Medicine·P WhittyE O'Callaghan
May 3, 2008·Clinical EEG and Neuroscience·Robert W McCarleyDean F Salisbury
Oct 7, 2008·World Psychiatry : Official Journal of the World Psychiatric Association (WPA)·Patrick D McGorryAlison Yung
Oct 22, 2008·Progress in Neuro-psychopharmacology & Biological Psychiatry·Müge Devrim-UçokAlp Uçok
Dec 3, 2008·Psychiatry Research·Adriano ZanelloMarco C G Merlo
Jan 2, 2009·The British Journal of Psychiatry : the Journal of Mental Science·Niall CrumlishEadbhard O'Callaghan
Feb 18, 2009·The Australian and New Zealand Journal of Psychiatry·Jae Seung ChangYong Sik Kim
Aug 4, 2009·Clinical Neurophysiology : Official Journal of the International Federation of Clinical Neurophysiology·David M AlexanderSteven M Silverstein
Sep 11, 2009·CNS Drugs·Kayvon SalimiJeffrey A Lieberman
Dec 4, 2009·Schizophrenia Bulletin·Julie KreyenbuhlUNKNOWN Schizophrenia Patient Outcomes Research Team (PORT)
Dec 4, 2009·Schizophrenia Bulletin·Lisa B DixonUNKNOWN Schizophrenia Patient Outcomes Research Team (PORT)
Dec 4, 2009·Schizophrenia Bulletin·Robert W BuchananUNKNOWN Schizophrenia Patient Outcomes Research Team (PORT)
Jan 5, 2010·NeuroImage·Devorah SegalPatrick R Hof
Jan 13, 2010·Neuropsychology·Carol JahshanKristin S Cadenhead

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