Diverse Effects of Noradrenaline and Adrenaline on the Quantal Secretion of Acetylcholine at the Mouse Neuromuscular Junction

Andrei N TsentsevitskyEllya A Bukharaeva


Despite the long history of investigations of adrenergic compounds and their biological effects, specific mechanisms of their action in distinct compartments of the motor unit remain obscure. Recent results have suggested that not only skeletal muscles but also the neuromuscular junctions represent important targets for the action of catecholamines. In this paper, we describe the effects of adrenaline and noradrenaline on the frequency of miniature endplate potentials, the quantal content of the evoked endplate potentials and the kinetics of acetylcholine quantal release in the motor nerve endings of the mouse diaphragm. Noradrenaline and adrenaline decreased the frequency of the spontaneous release of acetylcholine quanta. The effect of noradrenaline was prevented by the β adrenoreceptor blocker propranolol, whereas the action of adrenaline was abolished by the α adrenoreceptor antagonist phentolamine. Noradrenaline did not alter the quantal content of endplate potentials, while adrenaline suppressed the evoked release of acetylcholine. Blocking the α adrenoreceptors prevented the decrease in quantal secretion caused by adrenaline. Quantal release became more asynchronous under noradrenaline, as evidenced by a greater dispersi...Continue Reading


Apr 11, 2020·Cellular and Molecular Neurobiology·Venera Khuzakhmetova, Ellya Bukharaeva
Feb 22, 2021·Ageing Research Reviews·Osvaldo DelbonoMaria Laura Messi
Sep 6, 2020·Molecular and Cellular Neurosciences·Andrei TsentsevitskyEllya Bukharaeva
May 1, 2021·International Journal of Molecular Sciences·Ellya BukharaevaAndrei Tsentsevitsky
Jun 30, 2021·European Journal of Neurology : the Official Journal of the European Federation of Neurological Societies·Peter TrillenbergTobias Graf

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