Diverse expression of the K-1 antigen by cortico-medullary and reticular epithelial cells of the bursa of Fabricius in chicken and guinea fowl

Developmental and Comparative Immunology
Imre OláhH S Lillehoj

Abstract

The immunocytochemical study of the K-1 monoclonal antibody indicates that the epithelial components of the bursa of Fabricius of the chicken and guinea fowl express the K-1 positive molecule. During embryogenesis, the K-1 antigen expression appears together with the bud-formation. As the number of B cells increases in the developing follicle, the K-1 expression gradually diminishes in the medullary reticular epithelial cells and completely ceases by hatching, which suggests that the molecule is developmentally regulated. After hatching, the expression of the molecule is restricted to the sealing off zone of the lymphoepithelial or medullary region of the follicle: i.e. to the cortico-medullary (CM) epithelial cells and the follicle associated epithelium (FAE) supporting cells in guinea fowl and to the latter ones in the chicken. The expression of the K-1 antigen by these epithelial components may support their structural identity. After hatching, the K-1 molecule is restricted to the CM epithelial cells and/or FAE supporting cells, which suggests that the function of the embryonic epithelial bud is taken over by the CM epithelial cells. The K-1 positive CM epithelial cells form arches, which encompass blast-like cells. The pos...Continue Reading

References

Apr 1, 1990·European Journal of Immunology·M WuorelaP Toivanen
Mar 1, 1986·Poultry Science·I OláhI Törö
Dec 1, 1994·Annals of Anatomy = Anatomischer Anzeiger : Official Organ of the Anatomische Gesellschaft·E CiriacoJ A Vega
May 1, 1993·Veterinary Immunology and Immunopathology·B KaspersE P Lillehoj
Jun 8, 1999·Annual Review of Immunology·E Robey

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Citations

Aug 15, 2013·Veterinary Research Communications·Fei ZhouZhangyong Ning
Jan 12, 2016·Developmental and Comparative Immunology·Nándor NagyImre Oláh
Dec 1, 2009·Developmental and Comparative Immunology·Weifeng MaoHans H Cheng

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