Diverse firing properties and Aβ-, Aδ-, and C-afferent inputs of small local circuit neurons in spinal lamina I

Pain
Elisabete C FernandesBoris V Safronov

Abstract

Spinal lamina I is a key element of the pain processing system, which integrates primary afferent input and relays it to supraspinal areas. More than 90% of neurons in this layer are local circuit neurons, whose role in the signal processing is poorly understood. We performed whole-cell recordings in a spinal cord preparation with attached dorsal roots to examine morphological features and physiological properties of small local circuit neurons (n = 47) in lamina I. Cells successfully filled with biocytin (n = 17) had fusiform (n = 10), flattened (n = 4), and multipolar (n = 3) somatodendritic morphology; their axons branched extensively and terminated in laminae I-III. Intrinsic firing properties were diverse; in addition to standard tonic (n = 16), adapting (n = 7), and delayed (n = 6) patterns, small local circuit neurons also generated rhythmic discharges (n = 6) and plateau potentials (n = 10), the latter were suppressed by the L-type Ca(2+)-channel blocker nifedipine. The neurons received monosynaptic inputs from Aδ and C afferents and could generate bursts of spikes on the root stimulation. In addition, we identified lamina I neurons (n = 7) with direct inputs from the low-threshold Aβ afferents, which could be picked up...Continue Reading

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Citations

Oct 12, 2016·Pflügers Archiv : European journal of physiology·Carolina RozaJosé A López-García
Apr 16, 2019·Pain·Volodymyr KrotovNana Voitenko
Nov 23, 2017·Frontiers in Cellular Neuroscience·Volodymyr KrotovNana Voitenko
Jun 3, 2021·Journal of Clinical Medicine·Thomas PerreaultBarry C Gendron

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