Diverse impact of neuronal activity at θ frequency on hippocampal long-term plasticity

Journal of Neuroscience Research
Tomasz Wójtowicz, Jerzy W Mozrzymas

Abstract

Brain oscillatory activity is considered an essential aspect of brain function, and its frequency can vary from <1 Hz to >200 Hz, depending on the brain states and projection. Episodes of rhythmic activity accompany hippocampus-dependent learning and memory in vivo. Therefore, long-term synaptic potentiation (LTP) and long-term depression, which are considered viable substrates of learning and memory, are often experimentally studied in paradigms of patterned high-frequency (>50 Hz) and low-frequency (<5 Hz) stimulation. However, the impact of intermediate frequencies on neuronal plasticity remains less well understood. In particular, hippocampal neurons are specifically tuned for activity at θ frequency (4-8 Hz); this band contributes significantly to electroencephalographic signals, and it is likely to be involved in shaping synaptic strength in hippocampal circuits. Here, we review in vitro and in vivo studies showing that variation of θ-activity duration may affect long-term modification of synaptic strength and neuronal excitability in the hippocampus. Such θ-pulse-induced neuronal plasticity 1) is long-lasting, 2) may be built on previously stabilized potentiation in the synapse, 3) may produce opposite changes in synapti...Continue Reading

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Citations

Mar 13, 2016·Neuromodulation : Journal of the International Neuromodulation Society·Francesco Dose, Giuliano Taccola
Jun 21, 2017·Proceedings of the National Academy of Sciences of the United States of America·Anne Vassalli, Paul Franken
Jul 3, 2019·Frontiers in Cellular Neuroscience·Céline Drieu, Michaël Zugaro

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