Diverse Intrinsic Properties Shape Functional Phenotype of Low-Frequency Neurons in the Auditory Brainstem

Frontiers in Cellular Neuroscience
Hui HongJason Tait Sanchez

Abstract

In the auditory system, tonotopy is the spatial arrangement of where sounds of different frequencies are processed. Defined by the organization of neurons and their inputs, tonotopy emphasizes distinctions in neuronal structure and function across topographic gradients and is a common feature shared among vertebrates. In this study we characterized action potential firing patterns and ion channel properties from neurons located in the extremely low-frequency region of the chicken nucleus magnocellularis (NM), an auditory brainstem structure. We found that NM neurons responsible for encoding the lowest sound frequencies (termed NMc neurons) have enhanced excitability and fired bursts of action potentials to sinusoidal inputs ≤10 Hz; a distinct firing pattern compared to higher-frequency neurons. This response property was due to lower amounts of voltage dependent potassium (KV) conductances, unique combination of KV subunits and specialized sodium (NaV) channel properties. Particularly, NMc neurons had significantly lower KV1 and KV3 currents, but higher KV2 current. NMc neurons also showed larger and faster transient NaV current (INaT) with different voltage dependence of inactivation from higher-frequency neurons. In contrast,...Continue Reading

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Citations

Jan 17, 2019·Journal of Neurophysiology·David H Brown, Richard L Hyson
Jan 21, 2021·Journal of Neurophysiology·Elisabeth Koert, Thomas Kuenzel
Jun 29, 2021·The Journal of Comparative Neurology·Ali Jason Saleh, Hans Gerd Nothwang

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Software Mentioned

MATLAB
Clampex
Neurolucida Explorer
ImageJ
NEURON
GraphPad
Neurolucida
Clampfit
Prism
MEMBRANE

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