Diverse Long-Range Axonal Projections of Excitatory Layer 2/3 Neurons in Mouse Barrel Cortex

Frontiers in Neuroanatomy
Takayuki YamashitaCarl C H Petersen

Abstract

Excitatory projection neurons of the neocortex are thought to play important roles in perceptual and cognitive functions of the brain by directly connecting diverse cortical and subcortical areas. However, many aspects of the anatomical organization of these inter-areal connections are unknown. Here, we studied long-range axonal projections of excitatory layer 2/3 neurons with cell bodies located in mouse primary somatosensory barrel cortex (wS1). As a population, these neurons densely projected to secondary whisker somatosensory cortex (wS2) and primary/secondary whisker motor cortex (wM1/2), with additional axon in the dysgranular zone surrounding the barrel field, perirhinal temporal association cortex and striatum. In three-dimensional reconstructions of 6 individual wS2-projecting neurons and 9 individual wM1/2-projecting neurons, we found that both classes of neurons had extensive local axon in layers 2/3 and 5 of wS1. Neurons projecting to wS2 did not send axon to wM1/2, whereas a small subset of wM1/2-projecting neurons had relatively weak projections to wS2. A small fraction of projection neurons solely targeted wS2 or wM1/2. However, axon collaterals from wS2-projecting and wM1/2-projecting neurons were typically also...Continue Reading

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Citations

Jan 12, 2020·Brain Structure & Function·Kathleen S Rockland
Dec 14, 2018·Frontiers in Systems Neuroscience·Rahul Chaudhary, V Rema
Aug 2, 2019·Nature Reviews. Neuroscience·Carl C H Petersen
Jan 24, 2019·Frontiers in Systems Neuroscience·James F A Poulet, Sylvain Crochet
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Sep 10, 2019·Frontiers in Systems Neuroscience·Mehdi Adibi
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Oct 17, 2020·Current Opinion in Neurobiology·Vahid EsmaeiliCarl Ch Petersen
May 25, 2021·Computational and Structural Biotechnology Journal·Beomjong SongSangsu Bae
Jun 15, 2021·Frontiers in Neural Circuits·Nihaad Paraouty, Todd M Mowery
Jul 25, 2021·Nature Communications·L GodenziniL M Palmer

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Methods Mentioned

BETA
TeA
Patchseq

Software Mentioned

NeuroMorpho
Neurolucida Explorer
MultistackReg
Neurolucida
Neurolucida 64
Turboreg ImageJ

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