Diverse mechanisms for endogenous regeneration and repair in mammalian organs.

Nature
James M Wells, Fiona M Watt

Abstract

Mammalian organs comprise an extraordinary diversity of cell and tissue types. Regenerative organs, such as the skin and gastrointestinal tract, use resident stem cells to maintain tissue function. Organs with a lower cellular turnover, such as the liver and lungs, mostly rely on proliferation of committed progenitor cells. In many organs, injury reveals the plasticity of both resident stem cells and differentiated cells. The ability of resident cells to maintain and repair organs diminishes with age, whereas, paradoxically, the risk of cancer increases. New therapeutic approaches aim to harness cell plasticity for tissue repair and regeneration while avoiding the risk of malignant transformation of cells.

References

Jul 5, 2007·Developmental Cell·Qiao ZhouDouglas A Melton
Jul 7, 2009·Annual Review of Cell and Developmental Biology·Aaron M Zorn, James M Wells
Dec 23, 2011·The American Journal of Pathology·Xuefeng LiuRichard Schlegel
May 9, 2013·EMBO Molecular Medicine·Ashish S PatelBijan Modarai
Jun 12, 2013·Cell Metabolism·Jonathan L Tilly, David A Sinclair
Oct 8, 2013·Nature·Panteleimon RompolasValentina Greco
Mar 29, 2014·Nature·Robert A J SignerSean J Morrison
Jun 26, 2014·Diabetes·Francesco Rubino, Stephanie A Amiel
Jul 6, 2014·Cell Stem Cell·Arin B Aurora, Eric N Olson
Aug 6, 2014·Nature Biotechnology·Steven W LaneFiona M Watt
Aug 12, 2014·Cell Stem Cell·Rocio SanchoAxel Behrens
Dec 17, 2014·Nature Communications·Salvatore SimminiJacqueline Deschamps
Feb 11, 2015·Annual Review of Physiology·Ben Z Stanger
Jul 21, 2015·Nature Cell Biology·Wei-Yu LuStuart J Forbes
Dec 10, 2015·Nature·Caroline A LindemansAlan M Hanash
Dec 15, 2015·Integrative Biology : Quantitative Biosciences From Nano to Macro·Priyalakshmi ViswanathanFiona M Watt
Dec 25, 2015·Proceedings of the National Academy of Sciences of the United States of America·Benjamin D Simons
Jan 7, 2016·Development·Michael B Schultz, David A Sinclair
Jan 23, 2016·Nature·Michael Karin, Hans Clevers
Jan 27, 2016·Developmental Cell·Jayaraj Rajagopal, Ben Z Stanger
Mar 17, 2016·Nature Reviews. Molecular Cell Biology·Allyson J Merrell, Ben Z Stanger
Jun 12, 2016·The Journal of Investigative Dermatology·Brett ShookValerie Horsley
Jul 14, 2016·Nature Reviews. Molecular Cell Biology·Alexandra Avgustinova, Salvador Aznar Benitah

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Citations

Jul 11, 2018·Experimental Dermatology·Leopold Eckhart, Patrick L J M Zeeuwen
Jun 7, 2019·Science·Takanori Takebe, James M Wells
Oct 1, 2019·Journal of Nursing Scholarship : an Official Publication of Sigma Theta Tau International Honor Society of Nursing·Linda L ChlanAndre Terzic
Sep 29, 2019·Oral Diseases·Pei-Lun WengCatherine E Ovitt
Mar 11, 2020·Cardiovascular Research·Alexandra RiddellTamara P Martin
Aug 10, 2018·Nature Reviews. Genetics·Mukul TewaryPeter W Zandstra
Nov 28, 2018·World Journal of Diabetes·Rajendra Raghow
Nov 28, 2019·Biological Reviews of the Cambridge Philosophical Society·Danton H O'DayRobert J Huber
Aug 30, 2019·Nature Communications·Elizabeth J Bradbury, Emily R Burnside
Jun 7, 2020·Nature Reviews. Genetics·Joseph A Goldman, Kenneth D Poss
Dec 5, 2018·Genes & Development·John P Leach, Edward E Morrisey
Jun 30, 2019·Cellular and Molecular Life Sciences : CMLS·Hue M La, Robin M Hobbs
Sep 20, 2020·The Journal of Pharmacology and Experimental Therapeutics·A GiulianiL Calzà
Nov 28, 2020·Regenerative Medicine·Freya Leask, Andre Terzic
Jul 22, 2020·American Journal of Respiratory and Critical Care Medicine·Gianni CarraroBarry R Stripp
Dec 29, 2020·Frontiers in Bioengineering and Biotechnology·Yining Liu, Tatiana Segura
Jan 15, 2021·Scientific Reports·Viola OorschotGeorg Ramm
Feb 10, 2021·Regenerative Medicine·Andre Terzic
Jan 13, 2021·Nature Protocols·Hiroyuki KoikeTakanori Takebe
Feb 10, 2021·The Journal of Investigative Dermatology·Xiaolei DingSabine A Eming
Nov 13, 2020·International Journal of Radiation Oncology, Biology, Physics·Martha E LuitjeCatherine E Ovitt
Feb 25, 2021·Regenerative Medicine·Satsuki YamadaAndre Terzic
Feb 19, 2021·Experimental Dermatology·Anna Geueke, Catherin Niemann
Nov 7, 2020·Scientific Reports·Yaelim Lee, G V Shivashankar
Dec 7, 2018·Developmental and Comparative Immunology·José A Fernández RobledoMichael J Metzger
Dec 20, 2019·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·Jianping ZhangXian Wang
Jun 20, 2021·Biological Reviews of the Cambridge Philosophical Society·ZhiCao YueCheng-Ming Chuong
Aug 10, 2021·Blood·Ronjon Chakraverty, Takanori Teshima

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Methods Mentioned

BETA
gastric bypass

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