Diverse Molecular Targets for Chalcones with Varied Bioactivities

Medicinal Chemistry
Bo Zhou, Chengguo Xing

Abstract

Natural or synthetic chalcones with different substituents have revealed a variety of biological activities that may benefit human health. The underlying mechanisms of action, particularly with respect to the direct cellular targets and the modes of interaction with the targets, have not been rigorously characterized, which imposes challenges to structure-guided rational development of therapeutic agents or chemical probes with acceptable target-selectivity profile. This review summarizes literature evidence on chalcones' direct molecular targets in the context of their biological activities.

Citations

Jul 25, 2018·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Matheus de Freitas SilvaAndrea Tarozzi
Oct 3, 2018·Chemistry & Biodiversity·Vinícius R D PereiraAdemar A Da Silva Filho
Sep 5, 2020·Journal of Toxicology and Environmental Health. Part a·Karoline Soares de FreitasDenise Crispim Tavares
Sep 12, 2020·Bioscience Reports·Rawan Al-SahebOmar S Abu Abed
Dec 20, 2019·Parasitology Research·Raquel Nascimento das NevesSibele Borsuk
Aug 2, 2017·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Marcelo N GomesBruno J Neves
Nov 25, 2020·Journal of Drug Targeting·Dana ElkhalifaAshraf Khalil
Feb 3, 2021·Journal of Natural Products·Yina XiaoIk-Soo Lee
Nov 24, 2020·Archives of Pharmacal Research·Yong-Hyun KoChoon-Gon Jang
Nov 24, 2020·Chemické Zvesti·Helena D Janse van RensburgGisella Terre'Blanche
Nov 10, 2020·Chemical Reviews·Gina PorrasCassandra L Quave
Jun 3, 2021·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Malose J MphahleleYee Siew Choong
Jun 27, 2021·Journal of Molecular Modeling·Patricia R S WenceslauHamilton B Napolitano
Jul 3, 2021·Biomolecules·Yang OuyangQi Wu
Jul 3, 2021·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Ahmed M DeghadyAbeer Mera
May 11, 2017·Chemical Reviews·Chunlin ZhuangZhenyuan Miao
Aug 4, 2020·Mini Reviews in Medicinal Chemistry·Eduardo Bustos MassDennis Russowsky

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Methods Mentioned

BETA
xenograft
nuclear translocation
ELISA
NMR
X-ray

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