Diverse proteomic alterations in gastric adenocarcinoma

Proteomics
Qing-Ye HeJen-Fu Chiu

Abstract

Gastric adenocarcinoma is one of the most common cancers in Asian countries including China. Although its incidence rates in the West are lower than that in Asia, gastric cancer is still a major health problem worldwide, being second only to lung cancers in the number of deaths it causes. Helicobacter pylori infection has been identified as the major pathogen, but the detailed pathogenesis of gastric carcinoma remains elusive. Due to the lack of suitable and specific biomarkers for early detection, most cases of the disease are diagnosed at late stages and the survival rate is low. In this study, we used a proteomic approach to globally analyze the protein profiles of paired surgical specimens of primary gastric adenocarcinoma and nontumor mucosa aiming at identifying specific disease-associated proteins as potential clinical biomarkers and for carcinogenetic study. Compared to nontumor tissues, multiple protein alterations were found in tumor tissues. Some of these alterations involve variations in the expression of cytoskeleton proteins, including an increase in cytokeratin 8 and tropomyosin isoform and a decrease in cytokeratin 20. Co-up-regulations of heat-shock proteins and glycolytic enzymes were observed in tumor tissues...Continue Reading

Citations

Nov 29, 2013·Journal of Proteome Research·Priscila Ferreira AquinoPaulo C Carvalho
Feb 20, 2008·Analytical and Bioanalytical Chemistry·Jian-feng LinFu-kun Zhao
Dec 24, 2008·Digestive Diseases and Sciences·Ying LinRobert R Schade
May 30, 2013·Medical Oncology·Mohammad Zeeshan NajmSyed Akhtar Husain
May 19, 2007·Antioxidants & Redox Signaling·Laura Vanda PappKum Kum Khanna
Feb 12, 2009·Thyroid : Official Journal of the American Thyroid Association·Alessandra FranzoniGiuseppe Damante
Mar 1, 2007·Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences·Yan ShenGuang-Biao Zhou
Oct 28, 2008·BMC Medical Genomics·Oi Lian KonM Priyanthi Kumarasinghe
Aug 4, 2012·PloS One·Mariana Ferreira LealMarília de Arruda Cardoso Smith
Jan 26, 2012·European Journal of Endocrinology·Anastasios SofiadisCatharina Larsson
Jan 17, 2012·Journal of Clinical Biochemistry and Nutrition·Hitomi OkadaToshikazu Yoshikawa
Apr 3, 2012·World Journal of Gastroenterology : WJG·Nina KočevarRadovan Komel
Sep 14, 2013·Carcinogenesis·Eduardo Bertoli BelaiAna Paula Campanelli
Jul 3, 2013·Tumour Biology : the Journal of the International Society for Oncodevelopmental Biology and Medicine·Maria KabbageKarim Chahed
Feb 7, 2008·Digestive Diseases and Sciences·Wen-Jin DingYan-Shen Peng
Jul 19, 2012·Digestive Diseases and Sciences·Wei WangHui-Zhen Zhang
Aug 9, 2011·Expert Review of Proteomics·Hao HuYuquan Wei
Jul 27, 2010·Expert Review of Proteomics·Nagathihalli S NagarajNipun B Merchant
Jul 17, 2007·Journal of Pharmaceutical Sciences·Ana Ruiz-GarciaVicente G Casabo
Jul 10, 2012·Pathology·Hongjun ShiRichard Stubbs
Apr 14, 2012·Journal of Proteomics·Li-Ling LinHsueh-Fen Juan
Feb 1, 2015·Clinica Chimica Acta; International Journal of Clinical Chemistry·Jun ZhangJianwu Tang
Nov 10, 2006·Digestive and Liver Disease : Official Journal of the Italian Society of Gastroenterology and the Italian Association for the Study of the Liver·G NardoneP Arcari
Feb 1, 2008·Proteomics. Clinical Applications·Katie Wing-Kei Lam, Samuel Chun-Lap Lo
Feb 1, 2008·Proteomics. Clinical Applications·Franck BrouillardMario Ollero

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.