Diverse roles of Dpb2, the non-catalytic subunit of DNA polymerase ε

Current Genetics
Michał Dmowski, Iwona J Fijałkowska

Abstract

Timely progression of living cells through the cell cycle is precisely regulated. This involves a series of phosphorylation events which are regulated by various cyclins, activated in coordination with the cell cycle progression. Phosphorylated proteins govern cell growth, division as well as duplication of the genetic material and transcriptional activation of genes involved in these processes. A subset of these tightly regulated genes, which depend on the MBF transcription factor and are mainly involved in DNA replication and cell division, is transiently activated at the transition from G1 to S phase. A Saccharomyces cerevisiae mutant in the Dpb2 non-catalytic subunit of DNA polymerase ε (Polε) demonstrates abnormalities in transcription of MBF-dependent genes even in normal growth conditions. It is, therefore, tempting to speculate that Dpb2 which, as described previously, participates in the early stages of DNA replication initiation, has an impact on the regulation of replication-related genes expression with possible implications for genomic stability.

References

Mar 24, 2006·Nature·Nevan J KroganJack F Greenblatt
Jun 27, 2006·Proceedings of the National Academy of Sciences of the United States of America·Stephen E MoyerMichael R Botchan
Nov 23, 2006·Molecular and Cellular Biology·Joanna Bloom, Frederick R Cross
Jun 6, 2007·Cell Division·Seiji TanakaHiroyuki Araki
Sep 17, 2008·Molecular and Cellular Biology·Robertus A M de BruinCurt Wittenberg
Aug 24, 2010·Current Opinion in Cell Biology·Hiroyuki Araki
Aug 23, 2011·Molecular Cell·Andreas DoncicJan M Skotheim
Feb 16, 2012·The EMBO Journal·Francisco M Bastos de OliveiraMarcus B Smolka
Aug 17, 2012·Cell Cycle·Marcus B SmolkaRobertus A M de Bruin
Oct 5, 2012·Nucleic Acids Research·Isabelle IsozErik Johansson
Mar 7, 2013·Genes to Cells : Devoted to Molecular & Cellular Mechanisms·Yan Li, Hiroyuki Araki
Mar 19, 2013·Current Biology : CB·Sugopa SenguptaKarim Labib
Apr 18, 2013·PloS One·Michael R HarrisRobertus A M de Bruin
Jul 24, 2013·Nature Reviews. Molecular Cell Biology·Cosetta BertoliRobertus A M de Bruin
Mar 19, 2014·Molecular Microbiology·Ewa GrabowskaIwona J Fijalkowska
Oct 15, 2014·Proceedings of the National Academy of Sciences of the United States of America·Lance D LangstonMike E O'Donnell
Dec 30, 2014·The Journal of Biological Chemistry·Rais A GanaiErik Johansson
Jun 26, 2015·FEMS Microbiology Reviews·Adrianna SkonecznaMarek Skoneczny
Jan 19, 2016·Current Genetics·Abhijit S DeshmukhSuman Kumar Dhar
Apr 14, 2016·Current Genetics·Mariana C GadaletaEishi Noguchi
Jun 6, 2016·Trends in Cell Biology·Scott A LujanThomas A Kunkel
Aug 5, 2016·Current Genetics·Roger PalouDavid G Quintana

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Citations

Oct 25, 2017·Molecular and Cellular Biology·Manpreet KaurSandeep Saxena
Mar 4, 2018·Current Genetics·Anna Bębenek, Izabela Ziuzia-Graczyk
Mar 14, 2018·G3 : Genes - Genomes - Genetics·Alex BronsteinMartin Kupiec
Nov 24, 2018·Current Genetics·María Moriel-CarreteroBenjamin Pardo
Oct 2, 2019·International Journal of Molecular Sciences·Jose-Antonio Pedroza-GarciaCécile Raynaud
Dec 17, 2020·International Journal of Molecular Sciences·Milena Denkiewicz-KrukIwona J Fijalkowska

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