Diverse roles of fatty acid binding proteins (FABPs) in development and pathogenesis of cancers

Gene
Mina AmiriMohammad Hossein Nasr Esfahani

Abstract

One of the most importantly involved pathways in cancer development is fatty-acid signaling pathway. Synthesized lipids as energetic sources are consumed by cancer cells for proliferation, growth, survival, invasion and angiogenesis. Fatty acids as signaling compounds regulate metabolic and transcriptional networks, survival pathways and inflammatory responses. Aggregation of fatty acids with fatty acid binding proteins (FABPs) facilitates their transportation to different cell organelles. FABPs, a group of lipid binding proteins modulate fatty acid metabolism, cell growth and proliferation and cancer development. They may be used as tumor marker in some cancers. FABPs are expressed in most malignancies such as prostate, breast, liver, bladder and lung cancer which are associated with the incidence, proliferation, metastasis, invasion of tumors. This review introduces several isoforms of FABPs (FABP1-12) and summarizes their function and their possible roles in cancer development through some proposed mechanisms.

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Citations

Nov 21, 2019·Journal of Cellular and Molecular Medicine·Tongyan LiuQin Zhang
Oct 15, 2019·Journal of Cellular Physiology·Xiaoran MaChanggang Sun
Jul 28, 2019·Current Opinion in Lipidology·Umar RekhiMaria Febbraio
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