Diverse roles of macrophages in atherosclerosis: from inflammatory biology to biomarker discovery.

Mediators of Inflammation
Ting GuiYasuteru Muragaki

Abstract

Cardiovascular disease, a leading cause of mortality in developed countries, is mainly caused by atherosclerosis, a chronic inflammatory disease. Macrophages, which differentiate from monocytes that are recruited from the blood, account for the majority of leukocytes in atherosclerotic plaques. Apoptosis and the suppressed clearance of apoptotic macrophages (efferocytosis) are associated with vulnerable plaques that are prone to rupture, leading to thrombosis. Based on the central functions of macrophages in atherogenesis, cytokines, chemokines, enzymes, or microRNAs related to or produced by macrophages have become important clinical prognostic or diagnostic biomarkers. This paper discusses the impact of monocyte-derived macrophages in early atherogenesis and advanced disease. The role and possible future development of macrophage inflammatory biomarkers are also described.

References

May 15, 1992·Proceedings of the National Academy of Sciences of the United States of America·A L Witsell, L B Schook
Jan 1, 1992·Progress in Lipid Research·S Parthasarathy, S M Rankin
Aug 1, 1995·Clinical and Experimental Immunology·R N MainiM Feldmann
Aug 1, 1995·Respiration Physiology·T NakanoY Kawakami
Oct 18, 1996·The Journal of Biological Chemistry·S A SchreyerR C LeBoeuf
Nov 14, 1997·Nature Medicine·S Rowland-Jones
Nov 21, 1997·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·G WickQ Xu
Jan 14, 1999·The New England Journal of Medicine·R Ross
Mar 12, 1999·Arteriosclerosis, Thrombosis, and Vascular Biology·T S LeeL Y Chau
Nov 24, 1999·Atherosclerosis·T J Reape, P H Groot
Dec 22, 1999·The Journal of Immunology : Official Journal of the American Association of Immunologists·A KolE A Kurt-Jones
Feb 22, 2000·The Journal of Biological Chemistry·A D SchecterM B Taubman
Aug 10, 2000·Journal of the American College of Cardiology·J A de LemosP M Ridker
Mar 29, 2001·The Journal of Biological Chemistry·P KumarA E Koch
Oct 10, 2001·Current Biology : CB·P M HensonV A Fadok
Nov 7, 2001·Circulation·U SchönbeckP M Ridker
Mar 6, 2002·Circulation·Peter LibbyAttilio Maseri
Apr 5, 2002·Current Atherosclerosis Reports·Michael E RosenfeldStephen M Schwartz
May 16, 2002·Current Gastroenterology Reports·Carlo Catassi, Alessio Fasano
May 23, 2002·Current Infectious Disease Reports·Erwin Kurt Cullamar, Larry I. Lutwick
Jul 3, 2002·Circulation·Stefan BlankenbergUNKNOWN AtheroGene Investigators
Aug 24, 2002·Proceedings of the National Academy of Sciences of the United States of America·Rajendra K TangiralaIra G Schulman
Dec 13, 2002·Journal of Interventional Cardiology·Renu VirmaniAndrew Farb
Dec 20, 2002·Nature·Peter Libby
Jan 7, 2003·Nature Medicine·Karen Birmingham
Jul 19, 2003·Arteriosclerosis, Thrombosis, and Vascular Biology·Joseph J BoyleMartin R Bennett
Aug 26, 2003·The American Journal of Pathology·Piers Davenport, Peter G Tipping
Oct 22, 2003·The Journal of Clinical Investigation·Anna-Karin L RobertsonGöran K Hansson
Nov 11, 2003·The Journal of Immunology : Official Journal of the American Association of Immunologists·Duane R Wesemann, Etty N Benveniste
Jan 31, 2004·Arteriosclerosis, Thrombosis, and Vascular Biology·Zhiping ChenDaniel Simon
Mar 31, 2004·Biochemistry and Cell Biology = Biochimie Et Biologie Cellulaire·Vesa M Olkkonen, Timothy P Levine
Apr 9, 2004·The New England Journal of Medicine·John DaneshVilmundur Gudnason

❮ Previous
Next ❯

Citations

May 16, 2013·Journal of Neuroimmune Pharmacology : the Official Journal of the Society on NeuroImmune Pharmacology·Craig J SmithAdam Denes
Jul 28, 2013·Immunobiology·Ioana Madalina Fenyo, Anca Violeta Gafencu
Mar 20, 2013·Nature Reviews. Rheumatology·Gregg J SilvermanCaroline Grönwall
Jan 1, 2014·Future Neurology·Joseph S HudsonDavid M Hasan
Dec 19, 2013·Inflammation Research : Official Journal of the European Histamine Research Society ... [et Al.]·Ramiro MalgorDouglas J Goetz
Jan 5, 2013·Biochimica Et Biophysica Acta·Heon-Woo LeeYoung-Guen Kwon
Feb 23, 2013·Cellular and Molecular Life Sciences : CMLS·Bart LegeinEsther Lutgens
Jun 7, 2013·Current Opinion in Clinical Nutrition and Metabolic Care·Stephanie MaiwaldGeesje M Dallinga-Thie
Jun 29, 2015·Free Radical Biology & Medicine·Junsei Mimura, Ken Itoh
Aug 19, 2015·Proceedings of the National Academy of Sciences of the United States of America·Lingjun MengXiaodong Wang
Jul 18, 2016·The Journal of Nutritional Biochemistry·Merla J Hubler, Arion J Kennedy
Mar 16, 2013·Journal of Cellular and Molecular Medicine·Yuri V BobryshevAlexander N Smirnov
Nov 12, 2015·Evidence-based Complementary and Alternative Medicine : ECAM·Min WuLongtao Liu
Apr 25, 2013·Biochemical Pharmacology·Brigitta ButtariRachele Riganò
Oct 7, 2014·Journal of Biomedical Materials Research. Part B, Applied Biomaterials·Michal BabičDaniel Horák
May 23, 2015·Scandinavian Journal of Immunology·E IdzkowskaM Moniuszko
Jul 26, 2015·Biochemical and Biophysical Research Communications·Jiajie JiTong Qiao
May 28, 2014·The International Journal of Biochemistry & Cell Biology·Saranya RaviVictor M Darley-Usmar
Apr 22, 2015·European Journal of Pharmacology·Patrick Asare FordjourGuanwei Fan
Sep 23, 2014·Atherosclerosis·Pooja M Bhatt, Ramiro Malgor
Feb 5, 2013·Atherosclerosis·Christa ZollbrechtChristian Hengstenberg
Nov 26, 2013·Atherosclerosis·Florian J MayerMatthias Hoke
Dec 4, 2014·Analytica Chimica Acta·Julie A Stenken, Andreas J Poschenrieder
Nov 5, 2014·Nature Reviews. Cardiology·Giulia Chinetti-GbaguidiBart Staels
May 18, 2016·Progress in Lipid Research·Marthe-Susanna WegnerSabine Grösch
May 28, 2013·Acta histochemica·Vinay KantDinesh Kumar
Dec 12, 2012·Biochimica Et Biophysica Acta·Peter Huebener, Robert F Schwabe
Jun 24, 2014·Seminars in Immunology·Kate WicksKimberly A Mace
Sep 10, 2013·Diabetes Research and Clinical Practice·Xiao-yan GuAi-ping Wang
Apr 22, 2015·European Journal of Pharmacology·Mario RomanoAntonio Recchiuti
Feb 22, 2016·Journal of Biomechanics·Suphannee PongkitwitoonStefan Judex
Mar 8, 2016·The Journal of Investigative Dermatology·Alvise SchiavinatoGerhard Sengle

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