Diverse Secondary Metabolites from the Marine-Derived Fungus Dichotomomyces cejpii F31-1

Marine Drugs
Yan-Xiu ChenWen-Jian Lan

Abstract

By adding l-tryptophan and l-phenylalanine to GPY medium, twenty-eight compounds, including amides, polyketides, a sesquiterpenoid, a diterpenoid, a meroterpenoid, diketopiperazines, β-carbolines, fumiquinazolines, and indole alkaloids, were discovered from the marine-derived fungus Dichotomomyces cejpii F31-1, demonstrating the tremendous biosynthetic potential of this fungal strain. Among these compounds, four amides dichotomocejs A-D (1-4), one polyketide dichocetide A (5), and two diketopiperazines dichocerazines A-B (15 and 16) are new. The structures of these new compounds were determined by interpreting detailed spectroscopic data as well as calculating optical rotation values and ECD spectra. Obviously, Dichotomomyces cejpii can effectively use an amino acid-directed strategy to enhance the production of nitrogen-containing compounds. Dichotomocej A (1) displayed moderate cytotoxicity against the human rhabdomyosarcoma cell line RD with an IC50 value of 39.1 µM, and pityriacitrin (22) showed moderate cytotoxicity against the human colon carcinoma cell line HCT116 with an IC50 value of 35.1 µM.

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Citations

Jan 22, 2019·Natural Product Reports·Anthony R CarrollMichèle R Prinsep
Aug 23, 2019·Natural Product Research·Sharpkate ShakerWen-Jian Lan
Jun 20, 2020·Archiv der Pharmazie·Yang LiuGuishun Piao
Feb 6, 2020·Applied Microbiology and Biotechnology·Muhammad IbrarFariha Hasan
Jan 31, 2021·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Tímea SzabóMátyás Milen

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Datasets Mentioned

BETA
EF669956

Methods Mentioned

BETA
NMR
circular dichroism

Software Mentioned

Gaussian
SpecDis
BLAST

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