PMID: 11319164Apr 25, 2001Paper

Diversification of cyclooxygenase-2-derived prostaglandins in ovulation and implantation

Biology of Reproduction
H MatsumotoS K Dey

Abstract

Previous observations of ovulation and fertilization defects in cyclooxygenase-2 (COX-2)-deficient mice suggested that COX-2-derived ovarian prostaglandins (PGs) participate in these events. However, the specific PG and its mode of action were unknown. Subsequent studies revealed that mice deficient in EP(2), a PGE(2)-receptor subtype, have reduced litter size, apparently resulting from poor ovulation but more dramatically from impaired fertilization. Using a superovulation regimen and in vitro culture system, we demonstrate herein that the ovulatory process, not follicular growth, oocyte maturation, or fertilization, is primarily affected in adult COX-2- or EP(2)-deficient mice. Furthermore, our results show that in vitro-matured and -fertilized eggs are capable of subsequent preimplantation development. However, severely compromised ovulation in adult COX-2- or EP(2)-deficient mice is not manifested in immature (3-wk-old) COX-2- or EP(2)-deficient mice, suggesting that the process of ovulation is more dependent on PGs in adult mice. Although the processes of implantation and decidualization are defective in COX-2(-/-) mice, our present results demonstrate that these events are normal in EP(2)-deficient mice, as determined by ...Continue Reading

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Citations

Jan 5, 2002·Molecular Reproduction and Development·F NuttinckG Charpigny
Dec 20, 2003·Prostaglandins, Leukotrienes, and Essential Fatty Acids·Rachel J A HelliwellMurray D Mitchell
Jun 12, 2002·Contraception·Nongluck Sookvanichsilp, Pawitra Pulbutr
Nov 16, 2002·Prostaglandins & Other Lipid Mediators·Naonori Uozumi, Takao Shimizu
Apr 12, 2011·Molecular Human Reproduction·Jinwon EoJade Hyunjung Lim
Nov 7, 2008·Biology of Reproduction·Xiaofei SunSudhansu K Dey
Jun 8, 2012·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Shiro KurusuJoseph V Bonventre
Jun 22, 2007·International Journal of Gynecological Pathology : Official Journal of the International Society of Gynecological Pathologists·Alexandros D PolydoridesRebecca N Baergen
Nov 14, 2003·Reproductive Biology and Endocrinology : RB&E·Milo C Wiltbank, Joseph S Ottobre
Sep 4, 2004·Reproductive Biology and Endocrinology : RB&E·María GaytanFrancisco Gaytan
Mar 13, 2014·TheScientificWorldJournal·Naguib Salleh
Oct 31, 2001·Lancet·R J Norman
Jan 2, 2009·Reproduction : the Official Journal of the Society for the Study of Fertility·Shiro KurusuMitsumori Kawaminami
May 19, 2012·Reproduction : the Official Journal of the Society for the Study of Fertility·Rebecca J HobbsPierre Comizzoli
Mar 12, 2013·PPAR Research·Satoru MatsudaYasuko Kitagishi
Feb 20, 2007·Reproduction : the Official Journal of the Society for the Study of Fertility·Jiyoung HongSudhansu K Dey
Nov 26, 2009·The European Journal of Contraception & Reproductive Health Care : the Official Journal of the European Society of Contraception·S S Agrawal, M Alvin Jose
Nov 3, 2015·The Journal of Reproduction and Development·Akihito TakahashiHiromichi Matsumoto
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Jun 1, 2005·Reproductive Biomedicine Online·Stephen S PalmerSteve Arkinstall
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Dec 25, 2009·Developmental Dynamics : an Official Publication of the American Association of Anatomists·Sung Min HanMichael A Miller
Aug 16, 2005·Prostaglandins & Other Lipid Mediators·Haibin Wang, Sudhansu K Dey
Dec 15, 2010·Developmental Cell·Johnathan W EdmondsMichael A Miller
Jan 8, 2008·Developmental Biology·Yumi Hoshino, Eimei Sato
Mar 1, 2016·Semergen·A Alcántara MonteroA Alonso Verdugo
Jul 13, 2014·Reproductive Sciences·Hai-Ying LiuYan-Ting Zeng

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