Diversification of porcine MHC class II genes: evidence for selective advantage.

Immunogenetics
Erin S LuetkemeierLawrence B Schook

Abstract

The major histocompatibility complex (MHC) is an immunological gene-dense region of high diversity in mammalian species. Sus scrofa was domesticated by at least six independent events over Eurasia during the Holocene period. It has been hypothesized that the level and distribution of MHC variation in pig populations reflect genetic selection and environmental influences. In an effort to define the complexity of MHC polymorphisms and the role of selection in the generation of class II gene diversity (DQB, DRB1, and pseudogene PsiDRB3), DNA from globally distributed unrelated domestic pigs of European and Asian origins and a Suidae out-group was analyzed. The number of pseudogene alleles identified (PsiDRB3 33) was greater than those found in the expressed genes (DQB 20 and DRB1 23) but the level of observed heterozygosity (PsiDRB3 0.452, DQB 0.732, and DRB1 0.767) and sequence diversity (PsiDRB3 0.029, DQB 0.062, and DRB1 0.074) were significantly lower in the pseudogene, respectively. The substitution ratios reflected an excess of d (N) (DQB 1.476, DRB1 1.724, and PsiDRB3 0.508) and the persistence of expressed gene alleles suggesting the influence of balancing selection, while the pseudogene was undergoing purifying selection....Continue Reading

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Citations

Dec 15, 2012·Immunogenetics·Katerina A MoutouZissis Mamuris
Mar 26, 2009·Tissue Antigens·C-S HoD M Smith
May 17, 2012·Animal Genetics·Sabine E EsslerArmin Saalmueller
Aug 4, 2016·Immunogenetics·Ulrike GimsaSabine E Hammer

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