Diversified Variants of Astrovirus MLB2 in Patients Following Hematopoietic Stem Cell Transplantation and the Evolutionary Rates and Patterns of the Virus

Evolutionary Bioinformatics Online
Ke GuoYan Ye

Abstract

We assessed the quasispecies heterogeneity of a human astrovirus MLB2 (HAstV-MLB2-YJMGK) in immunocompromised patients following hematopoietic stem cell transplantation and performed genetic and evolutionary analyses of HAstV isolates circulating worldwide. The result showed that the virus had diversified variants and a strong positive selection in the patient, indicating that such patients may be a reservoir for astrovirus. The time to the most recent common ancestor of MLB2 and classic HAstVs was around 1800 years, and it has a decline in effective population size of HAstVs in the late 100 years.

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Citations

Nov 19, 2020·The Journal of General Virology·Chia-Ming SuCho-Hua Wan

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Datasets Mentioned

BETA
MK327365

Methods Mentioned

BETA
PCR

Software Mentioned

Geneious
MiSeq
MEGA
BEAST
Simplot

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