Oct 2, 2014

Effectiveness of fusion peptide-based vaccine TT-P0 on the dynamics of salmon lice (Lepeophtheirus salmonis) infection in Atlantic salmon (Salmo salar L.)

BioRxiv : the Preprint Server for Biology
Mathieu ThomasMario Pablo Estrada

Abstract

Infection with parasitic copepod salmon louse Lepeophtheirus salmonis , represents one of the most important limitations to sustainable Atlantic salmon ( Salmo salar L.) farming today in the North Atlantic region. The parasite exerts negative impact on health, growth and welfare of farmed fish as well as impact on wild salmonid populations. It is therefore central to ensure continuous low level of salmon lice with the least possible handling of the salmon and drug use. This necessitates development of an alternative preventive strategy that can document both effect on lice and that fish welfare is maintained in a satisfactory manner with high economic impact. To address this, vaccination is a cost-effective and environmentally free control approach avoiding the disadvantages of chemical and mechanical treatments. In this study, efficacy of a vaccine candidate (TT-P0), encompassing a peptide derived from ribosomal protein P0 and promiscuous T cell epitopes from tetanus toxin and measles virus, was validated post infestation with L. salmonis, at the lab-scale. The sampling results showed good potential of the TT-P0 vaccine in limiting the ectoparasite load, when administered intraperitoneal in the host, by affecting the total adu...Continue Reading

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Mentioned in this Paper

Biological Markers
Gene Polymorphism
Molecular Dynamics
Study
Short Tandem Repeat
Crops, Agricultural
Genes
Environment
Avian Crop
LUC7L3 gene

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