Diversion and Illicit Sale of Extended Release Tapentadol in the United States

Pain Medicine : the Official Journal of the American Academy of Pain Medicine
Richard C DartNabarun Dasgupta

Abstract

Prescription opioid analgesics are commonly prescribed for moderate to severe pain. An unintended consequence of prescribing opioid analgesics is the abuse and diversion of these medications. Tapentadol ER is a recently approved centrally acting analgesic with synergistic mechanisms of action: μ-opioid receptor agonism and inhibition of norepinephrine reuptake. We assessed the amount of diversion and related cost of obtaining tapentadol IR (Nucynta®) and tapentadol ER (Nucynta ER®) as well as other Schedule II opioid medications in street transactions in the United States using the Researched Abuse, Diversion and Addiction-Related Surveillance (RADARS®) System. The Drug Diversion Program measures the number of cases opened by 260 drug diversion investigators in 49 states. StreetRx(TM) uses a crowd-sourcing Website to collect the prices paid for licit or illicit drugs. The population-based rates of diversion were 0.003 (tapentadol IR), 0.001 (tapentadol ER), and 1.495 (other Schedule II opioid tablets) reports per 100,000 population. The tapentadol ER rate was lower than the other Schedule II opioid tablets (P < 0.001) and tapentadol IR (P= 0.004). Diversion rates based on drug availability were 0.03 (tapentadol IR), 0.016 (tape...Continue Reading

References

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Citations

Apr 25, 2017·Pain Management·Joseph V PergolizziJo Ann LeQuang
Jan 26, 2018·European Journal of Pain : EJP·J FariaR J Dinis-Oliveira
Jul 15, 2016·The Korean Journal of Pain·Eun Jung ChangKyung Hoon Kim
May 17, 2018·Pharmacoepidemiology and Drug Safety·Jacob A LebinRichard C Dart
Dec 4, 2019·Drugs·Pamela E MacintyreChristine A Huxtable
May 17, 2018·Journal of Medical Internet Research·Perrine CréquitPhilippe Ravaud
Jan 2, 2021·Forensic Science International : Synergy·Nicole S Jones, Jeffrey H Comparin
Aug 6, 2021·Anaesthesia and Intensive Care·Pamela E Macintyre

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Software Mentioned

RADARS
StreetRx

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