PMID: 16636307Apr 26, 2006Paper

Diversities of podocyte molecular changes induced by different antiproteinuria drugs

Experimental Biology and Medicine
Yan XingNa Guan

Abstract

Nephrin, podocin, CD2AP, and alpha-actinin-4 are important podocyte proteins that help maintain the integrity of the slit diaphragm and prevent proteinuria. Studies have shown that angiotensin-converting enzyme inhibitors, glucocorticoids, and all-trans retinoic acid (ATRA) have antiproteinuric effects. However, it is still unclear whether these drugs, with different pharmacological mechanisms, lead to a reduction in proteinuria by changing the expression and distribution of these important podocyte proteins. In this study, changes in the expression and distribution of nephrin, podocin, CD2AP, and alpha-actinin-4 were dynamically detected in Adriamycin-induced nephrotic (ADR) rats treated with three different drugs: lisinopril, prednisone, and ATRA. Nephropathy was induced by an intravenous injection of Adriamycin. After Adriamycin injection, rats received lisinopril, prednisone, and ATRA treatment, respectively. Renal tissues were collected at Days 3, 7, 14, and 28. The distribution and the expression of messenger RNA and protein of nephrin, podocin, CD2AP, and alpha-actinin-4 were detected by indirect immunofluorescence, real-time polymerase chain reaction, and Western blotting, respectively. With the intervention of lisinopr...Continue Reading

References

Mar 24, 2000·The British Journal of Dermatology·A Johnson, R A Chandraratna
May 3, 2000·Kidney International·M W Taal, B M Brenner
Jul 25, 2000·Journal of the American Society of Nephrology : JASN·Jürgen WagnerEberhard Ritz
Apr 24, 2001·Journal of the American Society of Nephrology : JASN·Ariela BenigniGiuseppe Remuzzi
Jul 13, 2001·Pulmonary Pharmacology & Therapeutics·I M Adcock
Jun 18, 2002·Laboratory Investigation; a Journal of Technical Methods and Pathology·Pauliina LuimulaHarry Holthöfer
Jul 10, 2002·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Darren J KellyRichard E Gilbert
Sep 10, 2002·American Journal of Physiology. Renal Physiology·Sanna LehtonenEero Lehtonen
Mar 28, 2003·Journal of the American Society of Nephrology : JASN·Akira SuzukiMasatsugu Hori
Jul 23, 2003·Journal of the American Society of Nephrology : JASN·Klaas KoopJan A Bruijn
Sep 10, 2003·Pediatric Nephrology : Journal of the International Pediatric Nephrology Association·Na GuanJiyun Yang
Sep 15, 2004·Pathology International·Na GuanJiyun Yang
Sep 24, 2004·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Young Ki LeeHirashi Kawachi
Sep 25, 2004·Experimental Biology and Medicine·Qingfeng FanJianghong Deng
Dec 23, 2004·Kidney International. Supplement·Sandra BlancoRamón Romero
Apr 12, 2005·Current Opinion in Nephrology and Hypertension·Tobias B Huber, Thomas Benzing
Jun 9, 2005·American Journal of Physiology. Renal Physiology·Farid NakhoulZaid Abassi
Jun 16, 2005·Kidney International·Michael R VaughanStuart J Shankland
Jul 5, 2005·Proceedings of the National Academy of Sciences of the United States of America·Sanna LehtonenMarilyn G Farquhar

❮ Previous
Next ❯

Citations

Oct 13, 2010·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Eva SchönenbergerMario Schiffer
Jan 9, 2015·Journal of the American Society of Nephrology : JASN·Limin LiKe Zen
Jan 29, 2011·Nephrology·Annemarie Hennessy, Angela Makris
Apr 5, 2013·PloS One·Xiqian LanPravin C Singhal
Mar 19, 2011·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Maribel Navarro-MuñozRamón Romero
May 28, 2013·BioMed Research International· Yu-Shengyou, Yu Li
Dec 29, 2009·Journal of Huazhong University of Science and Technology. Medical Sciences = Hua Zhong Ke Ji Da Xue Xue Bao. Yi Xue Ying De Wen Ban = Huazhong Keji Daxue Xuebao. Yixue Yingdewen Ban·Shan ChenChun Zhang
Dec 16, 2018·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·Mengjie SunZhihong Liu
Jan 25, 2008·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·Lan HeYuhao Li
Dec 31, 2011·The Journal of Steroid Biochemistry and Molecular Biology·Jun ZhengWeihua Gan

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.