Abstract
Rhodiola spp. are rare and endangered alpine plants widely used as medicines and food additives by many civilizations since ancient times. Their main effective ingredients (such as salidroside and p-tyrosol) are praised to exhibit pharmacologic effects on high-altitude sickness and possess anti-aging and other adaptogenic capacities based on their antioxidant properties. In this study, 347 endophytic fungi were isolated from R. crenulata, R. angusta, and R. sachalinensis, and the molecular diversity and antioxidant activities of these fungi were investigated for the first time. These fungi were categorized into 180 morphotypes based on cultural characteristics, and their rRNA gene ITS sequences were analyzed by BLAST search in the GenBank database. Except for 12 unidentified fungi (6.67%), all others were affiliated to at least 57 genera in 20 orders of four phyla, namely, Ascomycota (88.89%), Basidiomycota (2.78%), Zygomycota (1.11%), and Glomeromycota (0.56%), which exhibited high abundance and diversity. Antioxidant assay showed that the DPPH radical-scavenging rates of 114 isolates (63.33%) were >50%, and those of five isolates (Rct45, Rct63, Rct64, Rac76, and Rsc57) were >90%. The EC50 values of five antioxidant assays sug...Continue Reading
References
Jan 1, 1992·Natural Toxins·O PetriniO Viret
Nov 15, 1994·Archives of Biochemistry and Biophysics·T C DinisL M Almeida
Apr 9, 1993·Science·A StierleD Stierle
Feb 1, 1996·Microbiology·Gary StrobelW M Hess
Sep 8, 2001·Natural Product Reports·R X Tan, W X Zou
May 16, 2002·Phytochemistry·Gary StrobelRaymond Ming Wah Chau
Sep 6, 2003·Journal of Clinical Microbiology·P P BosshardM Altwegg
Dec 11, 2003·Microbiology and Molecular Biology Reviews : MMBR·Gary Strobel, Bryn Daisy
Feb 28, 2004·Journal of Natural Products·Gary StrobelJames Harper
Jun 29, 2004·Proceedings of the National Academy of Sciences of the United States of America·Rebecca J GanleyGeorge Newcombe
Feb 25, 2005·Proceedings of the National Academy of Sciences of the United States of America·Rusty Rodriguez, Regina Redman
Mar 4, 2005·Biological & Pharmaceutical Bulletin·Yong Chun SongRen Xiang Tan
Aug 3, 2006·Journal of Agricultural and Food Chemistry·Sun Young ChoiNak Ju Sung
Mar 3, 2007·Plant Cell Reports·Lan-Qing MaHe-Chun Ye
Aug 9, 2007·Mycologia·A Elizabeth ArnoldRytas Vilgalys
Dec 19, 2007·Letters in Applied Microbiology·L XuJ Wang
Feb 8, 2008·The ISME Journal·Rusty J RodriguezRegina S Redman
May 21, 2008·Studies in Mycology·Gi-Ho SungJoseph W Spatafora
Feb 25, 2009·The New Phytologist·R J RodriguezR S Redman
Dec 24, 2009·Physiologia Plantarum·James F White, Mónica S Torres
Jan 19, 2010·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·Vanita GuptaRatan Kumar
Apr 10, 2010·Phytomedicine : International Journal of Phytotherapy and Phytopharmacology·A PanossianJ Sarris
Nov 3, 2010·Phytomedicine : International Journal of Phytotherapy and Phytopharmacology·Shao Kang HungEdzard Ernst
Feb 10, 2011·Phytotherapy Research : PTR·Jin-long CuiPeigen Xiao
Feb 15, 2011·Phytomedicine : International Journal of Phytotherapy and Phytopharmacology·Hong Yin, Yu-Hong Sun
Aug 11, 2011·Journal of Pharmacy & Bioallied Sciences·Raman ChawlaRakesh Kumar Sharma
Apr 13, 2012·Journal of Agricultural and Food Chemistry·JinTong ZhaoChengBo Gu
May 31, 2012·BMC Complementary and Alternative Medicine·Sana IshaqueSunita Vohra
Jul 10, 2012·Life Sciences·Liwei SunYaw L Siow
Feb 26, 2013·Applied Microbiology and Biotechnology·Peng ZhengChengshu Wang
Jan 2, 2014·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·Hsiu-Mei ChiangKuo-Ching Wen
Apr 10, 2014·Journal of Agricultural and Food Chemistry·Yung-Hung ChuJung-Feng Hsieh
Jun 3, 2014·PloS One·Aurora Saucedo-GarcíaMaría C González
Aug 31, 2014·Phytomedicine : International Journal of Phytotherapy and Phytopharmacology·Alexander PanossianThomas Efferth
Jul 1, 2005·Comprehensive Reviews in Food Science and Food Safety·Farhath KhanumBrahm Singh
Citations
Jul 16, 2016·PloS One·Aline Silva Romão-DumaresqWelington Luiz Araújo
Oct 11, 2017·Nutrients·Ahsan HameedYuanda Song
Apr 13, 2018·PloS One·Fábio de Azevedo SilvaMarcos Antônio Soares
Apr 14, 2018·Scientific Reports·Xiao-Ming TanLi-Ying Yu
Jan 31, 2019·Molecular Plant-microbe Interactions : MPMI·Hui-Ling LiaoRytas Vilgalys
Feb 25, 2020·Environmental Microbiology·Jiayu ZhouRen Wang
May 23, 2017·Microbes and Environments·Takahiko Koizumi, Kazuhide Nara
Mar 15, 2019·BioMed Research International·Tahmina MonowarKathiresan V Sathasivam
Dec 12, 2019·BMC Microbiology·Xiaoxiang DuanJinyan Dong
Apr 8, 2020·BioMed Research International·Hefa Mangzira KemungBey-Hing Goh
May 6, 2020·3 Biotech·Tamara Fonseca Bastos SantosIolanda Cristina Silveira Duarte
Mar 24, 2018·Journal of the International Society of Sports Nutrition·Maha SellamiJohnny Padulo
Aug 23, 2019·Nutrients·Aneta LewickaSławomir Lewicki
Jun 6, 2020·Frontiers in Bioengineering and Biotechnology·Ayomide Emmanuel Fadiji, Olubukola Oluranti Babalola
Aug 11, 2020·Oxidative Medicine and Cellular Longevity·Changjiang GuGuoyong Yin
Aug 28, 2020·Frontiers in Microbiology·Rashmi MishraVemuri Venkateswara Sarma
Sep 22, 2017·Scientific Reports·Kuo-Cheng LanTe-I Weng
Feb 9, 2017·Applied Microbiology and Biotechnology·Rabia TanvirAamir Ghafoor Bajwa
Apr 25, 2018·Frontiers in Microbiology·Jin-Long CuiGang Zhang
Aug 10, 2018·Frontiers in Microbiology·Tuan Noraida Tuan HamzahRozi Mohamed
Oct 6, 2020·Frontiers in Microbiology·Xin-Guo ZhangXiao-Di Ma
Oct 5, 2019·Oxidative Medicine and Cellular Longevity·Ruru Li, Jianzong Chen
Dec 8, 2017·Journal of Immunology Research·Sławomir LewickiRobert Zdanowski
Oct 19, 2019·Nutrients·Yi-Hung LiaoChung-Yu Chen
Dec 8, 2020·Frontiers in Microbiology·Md Sohanur RahamanMd Amirul Islam
Jan 3, 2021·Biological Trace Element Research·Amr Hosny HashemSalem S Salem
Aug 11, 2019·International Journal of Biological Macromolecules·Jianxi SongHaibin Tong
Mar 2, 2021·Chinese Journal of Natural Medicines·Huan-Huan RenLi Yao
Mar 7, 2021·Journal of Fungi·Bartholomew Saanu Adeleke, Olubukola Oluranti Babalola
Mar 8, 2021·Archives of Microbiology·Adekunle Raimi, Rasheed Adeleke
May 1, 2020·Toxicon : Official Journal of the International Society on Toxinology·Mosaad A Abdel-WahhabIrwandi Jaswir
Jul 3, 2021·Journal of Fungi·Jameel R Al-ObaidiE I Ahmad-Kamil
Jul 3, 2021·Metabolites·Ali A BadawyAmr H Hashem
Jul 1, 2020·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·Fangfang FanXiaobo Wang
Jul 21, 2021·Chinese Medicine·Xiuzhu LiShengpeng Wang
Aug 3, 2021·Frontiers in Microbiology·Rahul JainSanjay Kumar
Aug 7, 2021·Journal of Fungi·Melissa H PecundoNan Li
Oct 6, 2021·Scientific Reports·Lixiang WangSenshan Wang