Diversity and fluctuation of spine morphology in CA1 pyramidal neurons after transient global ischemia

Journal of Neuroscience Research
Yi-Wen RuanZao C Xu

Abstract

Dendritic spines form postsynaptic components of excitatory synapses in CA1 pyramidal neurons and play a key role in excitatory signal transmission. Transient global ischemia is thought to induce excitotoxicity that triggers delayed neuronal death in the CA1 region. However, the mechanism underlying structural changes of excitatory synapses after ischemia is not completely understood. Here, we demonstrate how dendritic spines change in their density and structure at an acute stage after transient global ischemia. Intracellular staining in vivo showed that the total spine density in basal, proximal, and distal apical dendrites increased at 12 hr and 24 hr after ischemia, but returned to control levels at 48 hr after ischemia. Consistent increase of spine density mainly appeared in non-late depolarizing postsynaptic potential neurons, although late depolarizing postsynaptic potential neurons also showed slight increases in spine density in these dendrites at the same intervals after ischemia. Golgi staining showed increased spine density occurred in less swollen dendrites but decreased spine density appeared in severely swollen dendrites at 12 and 24 hr after ischemia. In addition, the density and percentage of stubby spines redu...Continue Reading

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Nov 1, 2006·Journal of Neuroscience Research·Yi-Wen RuanZao C Xu

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Citations

Jun 9, 2009·Histochemistry and Cell Biology·Dariusz Orlowski, Carsten R Bjarkam
Sep 27, 2015·Cryobiology·Robert L McIntyre, Gregory M Fahy
Jul 24, 2012·Neuroscience Letters·Chia-Chien ChenJoshua C Brumberg
Apr 24, 2012·Neuroscience·C X He, C Portera-Cailliau
Sep 25, 2014·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·Elena Blanco-SuárezJonathan G Hanley
Nov 8, 2017·Neuro-oncology·Joseph G DumanDavid R Grosshans
Jul 30, 2019·Clinical Psychopharmacology and Neuroscience : the Official Scientific Journal of the Korean College of Neuropsychopharmacology·Hülya HalisCem Süer
Feb 2, 2021·Frontiers in Neuroscience·Zhongshan ShiZao C Xu

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