Diversity and Inter-Connections in the CXCR4 Chemokine Receptor/Ligand Family: Molecular Perspectives

Frontiers in Immunology
Lukas PawigHeidi Noels

Abstract

CXCR4 and its ligand CXCL12 mediate the homing of progenitor cells in the bone marrow and their recruitment to sites of injury, as well as affect processes such as cell arrest, survival, and angiogenesis. CXCL12 was long thought to be the sole CXCR4 ligand, but more recently the atypical chemokine macrophage migration inhibitory factor (MIF) was identified as an alternative, non-cognate ligand for CXCR4 and shown to mediate chemotaxis and arrest of CXCR4-expressing T-cells. This has complicated the understanding of CXCR4-mediated signaling and associated biological processes. Compared to CXCL12/CXCR4-induced signaling, only few details are known on MIF/CXCR4-mediated signaling and it remains unclear to which extent MIF and CXCL12 reciprocally influence CXCR4 binding and signaling. Furthermore, the atypical chemokine receptor 3 (ACKR3) (previously CXCR7) has added to the complexity of CXCR4 signaling due to its ability to bind CXCL12 and MIF, and to evoke CXCL12- and MIF-triggered signaling independently of CXCR4. Also, extracellular ubiquitin (eUb) and the viral protein gp120 (HIV) have been reported as CXCR4 ligands, whereas viral chemokine vMIP-II (Herpesvirus) and human β3-defensin (HBD-3) have been identified as CXCR4 antag...Continue Reading

References

Jan 1, 1975·Proceedings of the National Academy of Sciences of the United States of America·G GoldsteinE A Boyse
Apr 11, 1990·Nucleic Acids Research·F LibertG Vassart
Jul 1, 1966·Proceedings of the National Academy of Sciences of the United States of America·J R David
Nov 15, 1993·Clinica Chimica Acta; International Journal of Clinical Chemistry·M OkadaY Hirasawa
Jan 1, 1996·Journal of Leukocyte Biology·T N WellsA E Proudfoot
May 28, 1996·Proceedings of the National Academy of Sciences of the United States of America·H W SunE Lolis
May 22, 1997·Nature·W WeissenhornD C Wiley
Sep 1, 1997·Nucleic Acids Research·S F AltschulD J Lipman
Feb 14, 1998·The Journal of Biological Chemistry·H E Hamm
May 23, 1998·FEBS Letters·A CaruzF Arenzana-Seisdedos
Aug 5, 1998·Proceedings of the National Academy of Sciences of the United States of America·Q MaT A Springer
Aug 14, 1999·The Journal of Biological Chemistry·A AmaraF Arenzana-Seisdedos
Jun 3, 2000·Annual Review of Immunology·D Rossi, A Zlotnik
Nov 22, 2000·The Journal of Biological Chemistry·J HarderJ M Schroder
Mar 30, 2001·The Journal of Biological Chemistry·C HerreraR Franco
Sep 26, 2001·The Journal of Biological Chemistry·G A McQuibbanC M Overall
Oct 20, 2001·The Journal of Biological Chemistry·A Marchese, J L Benovic

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Citations

Jan 24, 2016·The Journal of Investigative Dermatology·Romy Beatriz Christmann
Aug 15, 2015·International Journal of Psychology : Journal International De Psychologie·Kimberly A Noels, Richard Clément
Dec 25, 2015·Data in Brief·Joseph Ignatius IrudayamVaithilingaraja Arumugaswami
Mar 15, 2016·Cellular Signalling·Chiara ParraviciniIvano Eberini
Apr 6, 2016·Frontiers in Microbiology·Hanan Polansky, Adrian Javaherian
Jul 2, 2016·Immunology Letters·Tommaso PozzobonBarbara Molon
Oct 19, 2016·Biochimica Et Biophysica Acta. Molecular Cell Research·Eun-Kyung KwonNam-Hyuk Cho
Mar 31, 2017·Current Cardiovascular Imaging Reports·Malte Kircher, Constantin Lapa
Jun 24, 2017·Annals of Laboratory Medicine·Dong Woo ShinDong Soon Lee
Oct 13, 2017·International Journal of Clinical Oncology·Alireza NazariGholamhossein Hassanshahi
Dec 19, 2017·Frontiers in Endocrinology·Kate L LovelandHans-Christian Schuppe
Oct 31, 2017·Cellular & Molecular Immunology·Rik JanssensPaul Proost
Feb 23, 2019·Cells·Nanako KawaguchiToshio Nakanishi
Aug 27, 2016·Clinical Reviews in Allergy & Immunology·Juan J Nieto-FontarigoFrancisco J Salgado
Apr 26, 2019·Arteriosclerosis, Thrombosis, and Vascular Biology·Helen L SpencerPaolo Madeddu
Nov 18, 2017·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Yifan FengFei Yuan
Aug 20, 2019·Current Topics in Medicinal Chemistry·Khomson SuttisintongPornpan Pungpo
Mar 3, 2020·Journal of Cellular and Molecular Medicine·Yahong LiuLili Zhou
May 19, 2019·Clinical and Experimental Medicine·Guadalupe Avalos-NavarroAlicia Del Toro-Arreola
Jan 8, 2016·Journal of Leukocyte Biology·Alessandro VacchiniElena Monica Borroni
Apr 16, 2016·Tumour Biology : the Journal of the International Society for Oncodevelopmental Biology and Medicine·Zhidong WangYong Zhou
May 31, 2018·Calcified Tissue International·Kazuhiro ShimaHideki Kitaura
Oct 30, 2018·Journal of the American Heart Association·Josefin SoppertChristian Stoppe
Jan 30, 2020·The Quarterly Journal of Nuclear Medicine and Molecular Imaging : Official Publication of the Italian Association of Nuclear Medicine (AIMN) [and] the International Association of Radiopharmacology (IAR), [and] Section of the Society of Radiopharmaceutica·Mohamed Y ElwazirPanithaya Chareonthaitawee
Sep 29, 2020·Frontiers in Immunology·Marco E Bianchi, Rosanna Mezzapelle
Oct 22, 2016·Journal of Bone and Mineral Metabolism·Sher Bahadur PoudelJeong-Chae Lee
Sep 7, 2017·Current Medicinal Chemistry·Weiqiang ZhouGuangdi Wang
Aug 15, 2018·Annals of Nuclear Medicine·Malte KircherConstantin Lapa
Feb 15, 2019·Arteriosclerosis, Thrombosis, and Vascular Biology·Heidi NoelsRory R Koenen
Feb 8, 2019·Frontiers in Medicine·Aphrodite KapurniotuJürgen Bernhagen

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Methods Mentioned

BETA
ubiquitination
gel filtration
GTPase
fluorescence resonance
FRET
co-immunoprecipitation
transfection
xenograft

Clinical Trials Mentioned

NCT01458288

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