Diversity and modulation of ionic conductances in leech neurons

Journal of Neurobiology
A L Kleinhaus, J D Angstadt

Abstract

A complete understanding of animal behavior at the cellular level requires detailed information on the intrinsic biophysical properties of neurons, muscles, and the synaptic connections they make. In the past 10 to 15 years, electrophysiological studies of leech neurons have revealed a diverse array of voltage-gated ionic conductances distinguished by their pharmacological sensitivity to classic ion channel blockers. Voltage-clamp studies have provided new information about the kinetics and voltage-dependence of Na+ conductances, several K+ currents, including IA, IK and IK(Ca.), and high- and low-voltage-gated Ca2+ conductances. These studies showed that the action potentials of most leech neurons result from the usual sequence of permeability changes to Na+, K+, and Ca2+ ions. They also added insight as to the role played by particular combinations of conductances in providing individual neurons with electrical properties appropriate for the particular information they encode. Evidence is accumulating on the modulatory actions fo endogenous neurotransmitters such as FMRFamide, serotonin, and octopamine on motor behaviors in the animal. Parallel studies suggest that changes in behavior can be explained, at least in part, by th...Continue Reading

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Citations

Feb 6, 1998·Journal of Neuroscience Research·S Meis, J W Deitmer
Apr 20, 2005·Journal of Comparative Physiology. A, Neuroethology, Sensory, Neural, and Behavioral Physiology·James D AngstadtSarah M Levasseur
Jul 29, 2005·Cellular and Molecular Neurobiology·Francisco F De-Miguel, Citlali Trueta
Sep 30, 1998·The European Journal of Neuroscience·R Schätzthauer, P Fromherz
May 12, 2010·Journal of Neurophysiology·Kathryn B Grey, Brian D Burrell
Jun 4, 2014·Journal of Comparative Physiology. A, Neuroethology, Sensory, Neural, and Behavioral Physiology·James D Angstadt, Amanda M Simone
Jan 31, 2012·Behavioural Brain Research·Maria Luisa ZaccardiRossana Scuri
Dec 13, 2019·Frontiers in Physiology·Sonja MeiserJutta Kretzberg

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