Diversity and selectivity in mRNA translation on the endoplasmic reticulum

Nature Reviews. Neuroscience
David W Reid, Christopher V Nicchitta

Abstract

Pioneering electron microscopy studies defined two primary populations of ribosomes in eukaryotic cells: one freely dispersed through the cytoplasm and the other bound to the surface of the endoplasmic reticulum (ER). Subsequent investigations revealed a specialized function for each population, with secretory and integral membrane protein-encoding mRNAs translated on ER-bound ribosomes, and cytosolic protein synthesis was widely attributed to free ribosomes. Recent findings have challenged this view, and transcriptome-scale studies of mRNA distribution and translation have now demonstrated that ER-bound ribosomes also function in the translation of a large fraction of mRNAs that encode cytosolic proteins. These studies suggest a far more expansive role for the ER in transcriptome expression, where membrane and secretory protein synthesis represents one element of a multifaceted and dynamic contribution to post-transcriptional gene expression.

References

Apr 15, 1992·Proceedings of the National Academy of Sciences of the United States of America·B S Negrutskii, M P Deutscher
May 3, 1991·Cell·S M Simon, G Blobel
Jun 1, 1991·Proceedings of the National Academy of Sciences of the United States of America·B S Negrutskii, M P Deutscher
Jan 1, 1986·The Journal of Cell Biology·M A McCloskey, M M Poo
Sep 25, 1974·Journal of Molecular Biology·N BorgeseD D Sabatini
Mar 15, 1973·Journal of Molecular Biology·D BorgeseD D Sabatini
Dec 1, 1980·Proceedings of the National Academy of Sciences of the United States of America·P Walter, G Blobel
Feb 14, 1995·Proceedings of the National Academy of Sciences of the United States of America·A N Fedorov, T O Baldwin
Jan 1, 1994·Annual Review of Cell Biology·P Walter, A E Johnson
Aug 1, 1994·The Journal of Cell Biology·K U KaliesT A Rapoport
Feb 1, 1993·The Journal of Cell Biology·A J Savitz, D I Meyer
Aug 26, 1998·Proceedings of the National Academy of Sciences of the United States of America·C C KopczynskiG M Rubin
Dec 28, 1999·Annual Review of Cell and Developmental Biology·A E Johnson, M A van Waes
Aug 5, 2000·The Journal of Biological Chemistry·M D Potter, C V Nicchitta
Aug 10, 2000·The Journal of Biological Chemistry·R M Seiser, C V Nicchitta
Oct 19, 2000·The Journal of Biological Chemistry·R LevyG Kreibich
Nov 1, 2001·Annual Review of Cell and Developmental Biology·I M Palacios, D St Johnston

❮ Previous
Next ❯

Citations

Oct 5, 2015·Cellular and Molecular Life Sciences : CMLS·Dianne S Schwarz, Michael D Blower
Oct 31, 2015·Current Opinion in Chemical Biology·Margaret M Elvekrog, Peter Walter
Apr 27, 2016·The Journal of Cell Biology·Wolf HeusermannNicole C Meisner-Kober
Jul 12, 2016·Progress in Histochemistry and Cytochemistry·Julia A MakarovaAlexander G Tonevitsky
Apr 28, 2016·The Journal of Comparative Neurology·Li-Qing JinMichael E Selzer
Nov 14, 2016·Advances in Biological Regulation·Mark K CrowderRaymond D Blind
Oct 21, 2016·British Journal of Pharmacology·Wei HuDongjin Wang
May 11, 2017·RNA Biology·Juana Díez, Jennifer Jungfleisch
Feb 15, 2018·Cold Spring Harbor Perspectives in Biology·Ronald C Wek
Jun 28, 2017·Molecular and Cellular Biology·Appolinaire A OlouVimla Band
Oct 13, 2017·Journal of Virology·Ana QuintasYolanda Revilla
May 14, 2016·G3 : Genes - Genomes - Genetics·Matthew J MaurerSusan Michaelis
Mar 31, 2019·Molecular Cancer·Nancy T CheeShaun P Brothers
Apr 17, 2019·Traffic·Urko Del CastilloAhna R Skop
Apr 14, 2017·EMBO Reports·Vidhya RangarajuErin M Schuman
Oct 30, 2015·RNA Biology·Vincent P Mauro, Daiki Matsuda
Sep 30, 2018·Scientific Reports·Wing-Yiu Jason LeeRichard D Sloan
Nov 4, 2016·Nature Reviews. Molecular Cell Biology·Bin Tian, James L Manley
Jun 18, 2016·Science·Bin WuRobert H Singer
Apr 25, 2020·The Journal of Cell Biology·Dan Li, Jianlong Wang
Jul 4, 2020·Genes & Development·Dasa LongmanJavier F Cáceres
Aug 21, 2019·Nature Chemical Biology·Young-Chan KimHyo-Soo Kim
Aug 16, 2016·Journal of Assisted Reproduction and Genetics·D BebbereS Ledda
Sep 6, 2018·Proceedings of the National Academy of Sciences of the United States of America·Andrew W Folkmann, Geraldine Seydoux
Mar 7, 2020·Cells·Erik A BlackwoodChristopher C Glembotski
Oct 8, 2016·Transcription·Didier Auboeuf
Aug 31, 2017·Annual Review of Genetics·Christine Mayr
Apr 21, 2019·The Journal of Biological Chemistry·Alyson M HoffmanChristopher V Nicchitta
Apr 6, 2019·Advances in Pharmacological Sciences·Adaze Bijou EnogieruOkobi Eko Ekpo
Nov 9, 2016·Genome Research·Jennifer JungfleischJuana Díez
Mar 23, 2018·Frontiers in Genetics·Michael S ParkerSteven L Parker
Oct 10, 2018·Frontiers in Genetics·Bünyamin Akgül, İpek Erdoğan
Feb 6, 2020·Frontiers in Cardiovascular Medicine·Adrian ArrietaChristopher C Glembotski
Feb 14, 2020·International Journal of Molecular Sciences·Shannon E DoughertyGustavo M Silva

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.