PMID: 9162096Jan 1, 1997Paper

Diversity associated with the second expressed HLA-DRB locus in the human population

Immunogenetics
F RobbinsR J Hartzman

Abstract

Although diversity within the HLA-DRB region is predominantly focused in the DRB1 gene, the second expressed DRB loci, DRB3, DRB4, and DRB5, also exhibit variation. Within DRB1(*)15 or DRB1(*)16 haplotypes, four new variants were identified: 1) two new DRB5 alleles, DRB5*0104 and DRB5*0204, 2) a haplotype carrying a DRB1(*)15 or *16 allele without the usual accompanying DRB5 allele, and 3) a haplotype carrying a DRB5(*)0101 allele without a DRB1(*)15 or *16 allele. The evolutionary origins of these haplotypes were postulated based on their associations with the DRB6 pseudogene. Within HLA haplotypes which carry DRB3, a new DRB3(*)0205 allele and one unusual DRB3 association were identified. Finally, two new null DRB4 alleles are described: DRB4(*)0201N, which exhibits a deletion in the second exon, and a second allele, DRB4(*)null, which lacks the second exon completely. Gene conversion-like events and variation in the number of functional genes through reciprocal recombination and inactivation contribute to the diversity observed in the second expressed HLA-DRB loci.

Citations

Mar 2, 2002·Human Immunology·Ting F TangCarolyn Katovich Hurley
Apr 15, 1999·Tissue Antigens·M D CurranD Middleton
Mar 7, 2000·Tissue Antigens·C E VoorterE M van den Berg-Loonen
May 20, 2003·Tissue Antigens·C E M VoorterE M van den Berg-Loonen
Feb 8, 2005·Human Immunology·Wendy T N SwelsenElla M van den Berg-Loonen
Mar 22, 2019·HLA : Immune Response Genetics·Cristina Abad-MolinaAntonio Orduña-Domingo
Sep 7, 2017·International Journal of Immunogenetics·A E KennedyM T Dorak
Oct 4, 2008·The Journal of Immunology : Official Journal of the American Association of Immunologists·Stacy J CaillierJorge R Oksenberg
Dec 12, 2001·The Journal of Immunology : Official Journal of the American Association of Immunologists·Y WatanabeP Parham
Mar 28, 2018·Human Immunology·Noriko K SteinerCarolyn Katovich Hurley

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