PMID: 10607674Dec 23, 1999

Diversity in protein recognition by PTB domains

Current Opinion in Structural Biology
J D Forman-Kay, Tony Pawson


Phosphotyrosine-binding (PTB) domains were originally identified as modular domains that recognize phosphorylated Asn-Pro-Xxx-p Tyr-containing proteins. Recent binding and structural studies of PTB domain complexes with target peptides have revealed a number of deviations from the previously described mode of interaction, with respect to both the sequences of possible targets and their structures within the complexes. This diversity of recognition by PTB domains extends and strengthens our general understanding of modular binding domain recognition.


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Related Concepts

Complex (molecular entity)
Phosphotyrosine Binding Domain
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