journal cover

Diversity in the CDR3 region of V(H) is sufficient for most antibody specificities

Immunity

Aug 10, 2000

J L Xu, M M Davis

Abstract

All rearranging antigen receptor genes have one or two highly diverse complementarity determining regions (CDRs) among the six that typically form the ligand binding surface. We report here that, in the case of antibodies, diversity at one of these regions, CDR3 of the V(H) domain, is s...read more

Mentioned in this Paper

CDR2 gene
CDR1 protein, human
Founder Mice, Transgenic
IgG2B
IgM2
Immunoglobulin Heavy Chain Subgroup VH-III
Complementarity Determining Regions
Ligand Binding
Kappa-Immunoglobulin Subgroup VK-21
Framework Region, Immunoglobulin
234
Paper Details
References
  • References50
  • Citations242
12345...

Diversity in the CDR3 region of V(H) is sufficient for most antibody specificities

Immunity

Aug 10, 2000

J L Xu, M M Davis

PMID: 10933393

DOI: 10.1016/s1074-7613(00)00006-6

Abstract

All rearranging antigen receptor genes have one or two highly diverse complementarity determining regions (CDRs) among the six that typically form the ligand binding surface. We report here that, in the case of antibodies, diversity at one of these regions, CDR3 of the V(H) domain, is s...read more

Mentioned in this Paper

CDR2 gene
CDR1 protein, human
Founder Mice, Transgenic
IgG2B
IgM2
Immunoglobulin Heavy Chain Subgroup VH-III
Complementarity Determining Regions
Ligand Binding
Kappa-Immunoglobulin Subgroup VK-21
Framework Region, Immunoglobulin
234
Paper Details
References
  • References50
  • Citations242
12345...
/papers/diversity-in-the-cdr3-region-of-vh-is-sufficient/10933393