Diversity of activator of G-protein signaling (AGS)-family proteins and their impact on asymmetric cell division across taxa.

Developmental Biology
Florence D M Wavreil, Mamiko Yajima

Abstract

Asymmetric cell division (ACD) is a cellular process that forms two different cell types through a cell division and is thus critical for the development of all multicellular organisms. Not all but many of the ACD processes are mediated by proper orientation of the mitotic spindle, which segregates the fate determinants asymmetrically into daughter cells. In many cell types, the evolutionarily conserved protein complex of Gαi/AGS-family protein/NuMA-like protein appears to play critical roles in orienting the spindle and/or generating the polarized cortical forces to regulate ACD. Studies in various organisms reveal that this conserved protein complex is slightly modified in each phylum or even within species. In particular, AGS-family proteins appear to be modified with a variable number of motifs in their functional domains across taxa. This apparently creates different molecular interactions and mechanisms of ACD in each developmental program, ultimately contributing to developmental diversity across species. In this review, we discuss how a conserved ACD machinery has been modified in each phylum over the course of evolution with a major focus on the molecular evolution of AGS-family proteins and its impact on ACD regulation.

References

Nov 1, 1983·Developmental Biology·J E SulstonJ N Thomson
Jul 1, 1995·Trends in Biochemical Sciences·J R LambP Hieter
Feb 1, 1996·Mechanisms of Development·R SchnabelH Schnabel
Oct 12, 1999·BioEssays : News and Reviews in Molecular, Cellular and Developmental Biology·G L Blatch, M Lässle
Nov 24, 1999·The Journal of Biological Chemistry·A TakesonoS M Lanier
Dec 20, 2000·Proceedings of the National Academy of Sciences of the United States of America·L De VriesM G Farquhar
Feb 18, 2003·Proceedings of the National Academy of Sciences of the United States of America·Tarik F HaydarPasko Rakic
Mar 19, 2003·The Journal of Cell Biology·Meng-Fu Bryan TsouLesilee S Rose
May 6, 2003·Genes & Development·Dayalan G SrinivasanSander van den Heuvel
Nov 15, 2003·Current Biology : CB·Bob Goldstein
Dec 9, 2003·Trends in Biochemical Sciences·Luca D D'Andrea, Lynne Regan
Jan 3, 2004·Nature Neuroscience·Stephen C NoctorArnold R Kriegstein
Jun 11, 2004·Annual Review of Biochemistry·Francis S WillardDavid P Siderovski
Aug 25, 2004·Current Biology : CB·Jörg Betschinger, Jürgen A Knoblich

❮ Previous
Next ❯

Citations

Oct 2, 2021·Biology Open·Emily A Schiller, Dan T Bergstralh

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

© 2021 Meta ULC. All rights reserved