Diversity of assessing circulating tumor cells (CTCs) emphasizes need for standardization: a CTC Guide to design and report trials

Cancer Metastasis Reviews
S BüngerJ K Habermann

Abstract

Hematogenous spreading of tumor cells from primary tumors is a crucial step in the cascade to metastasis, the latter being the most limiting factor for patients' survival prognosis. Therefore, circulating tumor cells (CTCs) have become a field of intensive research. However, the process of isolation and identification of CTCs lacks standardization. This article presents an overview of 71 CTC studies reported in PUBMED since 2000 and focusing on colorectal cancer. These studies are evaluated regarding standardization of CTC isolation and identification, marker proteins used, study population and blood sample quality management, clinical performance, and quality measures. Overall, standardization of CTC assessment seems insufficient. Thus, comparability of CTC studies is hampered and results should be interpreted carefully. We here propose a standardized CTC guideline (CTC Guide) to prospectively design and report studies/trials in a harmonized form. Despite the current interstudy heterogeneity, the data indicate that CTC detection is of clinical relevance and CTCs should be considered as a surrogate prognostic marker. Many studies indicate the high potential for CTCs as prognostic markers, e.g., in colorectal cancer treatment. H...Continue Reading

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Citations

Mar 5, 2016·Cancer Metastasis Reviews·Aleš Ryška
Aug 30, 2019·Cells·Elisabetta Rossi, Francesco Fabbri
Apr 5, 2016·Asian Pacific Journal of Cancer Prevention : APJCP·Mehdi SahmaniMehdi Azad
Jan 7, 2017·Journal of Translational Medicine·Stefan SchreierWannapong Triampo
May 16, 2019·Journal of Hematology & Oncology·Petra BankóAndrás Telekes
May 6, 2019·Cancer Metastasis Reviews·Tania MamdouhiBaolin Zhang
Apr 17, 2021·Critical Reviews in Oncology/hematology·Tito Palmela LeitãoLuís Costa

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