PMID: 9542926May 23, 1998Paper

Diversity of DNA fingerprints of Mycobacterium tuberculosis isolates in the United States

Journal of Clinical Microbiology
Z H YangM D Cave

Abstract

To investigate the diversity of IS6110 fingerprints of Mycobacterium tuberculosis isolates in the United States and to determine if matching IS6110 fingerprints represent recent interstate tuberculosis transmission, we performed restriction fragment length polymorphism analysis of M. tuberculosis isolates from 1,326 patients in three geographically separated states. Seven hundred ninety-five different IS6110 fingerprint patterns were generated, and pattern diversity was similar in each state. Ninety-six percent of the fingerprint patterns were observed in only one state, demonstrating that most IS6110 fingerprint patterns are confined to a single geographic location. Of the IS6110 fingerprint patterns that were shared by isolates from more than one state, most isolates with 1 to 5 IS6110 copies were separable by pTBN12 fingerprinting whereas those with > 15 copies were not. One high-copy-number M. tuberculosis strain had identical IS6110 and pTBN12 fingerprints and included 57 isolates from three states. Epidemiological data demonstrated significant recent transmission of tuberculosis within each city but not among the states. This suggests that identical fingerprints of isolates from geographically separate locations most like...Continue Reading

References

Jan 11, 1990·Nucleic Acids Research·D ThierryJ L Guesdon
Nov 1, 1988·Journal of Clinical Microbiology·K D EisenachJ H Bates
Jul 1, 1983·Analytical Biochemistry·A P Feinberg, B Vogelstein
Oct 10, 1980·Nucleic Acids Research·M G Murray, W F Thompson
May 1, 1996·Journal of Clinical Microbiology·F ChavesM D Cave
Feb 1, 1997·American Journal of Respiratory and Critical Care Medicine·F ChavesJ H Bates
Mar 1, 1997·American Journal of Respiratory and Critical Care Medicine·W J BurmanM D Cave

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Citations

Jul 2, 2002·American Journal of Respiratory and Critical Care Medicine·Stephen E WeisPeter F Barnes
Nov 28, 2002·Emerging Infectious Diseases·Lauren S Cowan, Jack T Crawford
Sep 19, 2003·The New England Journal of Medicine·Peter F Barnes, M Donald Cave
Apr 9, 2008·Emerging Infectious Diseases·Melinda J WilkinsMatthew L Boulton
Mar 6, 2004·Microbial Drug Resistance : MDR : Mechanisms, Epidemiology, and Disease·Riza DurmazErcument Evliyaoglu
May 18, 2006·Emerging Infectious Diseases·UNKNOWN European Concerted Action on New Generation Genetic Markers and Techniques for the Epidemiology and Control of Tuberculosis
Oct 5, 2006·American Journal of Public Health·McKenzie AndrePeter D McElroy
Jul 27, 2002·Emerging Infectious Diseases·Judith R GlynnDick van Soolingen
Nov 28, 2002·Emerging Infectious Diseases·Barbara A EllisUNKNOWN National Tuberculosis Genotyping and Surveillance Network Work Group
May 24, 2001·Current Opinion in Pulmonary Medicine·H A Fletcher
Jan 25, 2002·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Samuel J McConkeyThomas C Bailey
Sep 7, 2000·Transactions of the Royal Society of Tropical Medicine and Hygiene·F C FandinhoL S Fonseca
May 8, 2004·Molecular Microbiology·Hassan SafiSusan T Howard
Oct 17, 2006·Clinical Microbiology Reviews·Barun MathemaBarry N Kreiswirth
Jan 31, 2002·Proceedings of the National Academy of Sciences of the United States of America·Megan Murray
Aug 2, 2000·Journal of Clinical Microbiology·M L BeggsM D Cave
Apr 28, 2001·Journal of Clinical Microbiology·U R DahleD A Caugant
Aug 30, 2001·Journal of Clinical Microbiology·A KrüünerG Källenius
Apr 16, 1999·Journal of Clinical Microbiology·J W DaleZ F Zainuddin
Nov 18, 2003·Clinical Microbiology and Infection : the Official Publication of the European Society of Clinical Microbiology and Infectious Diseases·R DurmazM D Cave

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