Diversity of GABAergic interneurons in layer VIa and VIb of mouse barrel cortex

Cerebral Cortex
Quentin PerrenoudThierry Gallopin

Abstract

Neocortical layer VI modulates the thalamocortical transfer of information and has a significant impact on sensory processing. This function implicates local γ-aminobutyric acidergic (GABAergic) interneurons that have only been partly described at the present time. Here, we characterized 85 layer VI GABAergic interneurons in acute slices of mouse somatosensory barrel cortex, using whole-cell current-clamp recordings, single-cell reverse transcription-polymerase chain reaction, and biocytin labeling followed by Neurolucida reconstructions. Unsupervised clustering based on electrophysiological molecular and morphological properties disclosed 4 types of interneurons. The 2 major classes were fast-spiking cells transcribing parvalbumin (PV) (51%) and adapting interneurons transcribing somatostatin (SOM) (26%). The third population (18%) transcribed neuropeptide Y (NPY) and appeared very similar to neurogliaform cells. The last class (5%) was constituted by well-segregated GABAergic interneurons transcribing vasoactive intestinal peptide (VIP). Using transgenic mice expressing GFP under the control of the glutamic acid decarboxylase 67k (GAD67) promoter, we investigated the densities of GABAergic cells immunolabeled against PV, SOM,...Continue Reading

References

Feb 1, 1991·Journal of Neurophysiology·H J Luhmann, D A Prince
Oct 1, 1985·Journal of Neurophysiology·D A McCormickD A Prince
Jan 1, 1994·The Japanese Journal of Physiology·K Kuba
Jun 1, 1997·Cerebral Cortex·Y Gonchar, A Burkhalter
Sep 1, 1997·Cerebral Cortex·Y Kawaguchi, Y Kubota
Mar 28, 1998·The European Journal of Neuroscience·K Obst, P Wahle
Apr 15, 1995·Physical Review. B, Condensed Matter·C DouketisM Moskovits
Sep 24, 1999·The Journal of Comparative Neurology·X B Liu, E G Jones
May 24, 2000·Proceedings of the National Academy of Sciences of the United States of America·B CauliE Audinat
May 2, 2001·The Journal of Comparative Neurology·B ClancyM J Friedlander
Jun 20, 2001·Journal of Neurochemistry·K TsuzukiS Ozawa
Oct 5, 2002·Journal of Neurophysiology·Michael Beierlein, Barry W Connors
Mar 11, 2003·Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences·Adam M Sillito, Helen E Jones
Mar 22, 2003·Science·Gábor TamásJános Szabadics
Mar 27, 2004·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Fuyuki KarubeYasuo Kawaguchi
Jul 30, 2004·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Laurence BayerMichel Mühlethaler
Sep 21, 2004·Nature Reviews. Neuroscience·Henry MarkramCaizhi Wu
Aug 12, 2005·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Michael A LongBarry W Connors
Dec 13, 2005·Cerebral Cortex·Thierry GallopinBertrand Lambolez
Jan 18, 2006·Science·János SzabadicsGábor Tamás
May 12, 2006·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Yunyong MaAriel Agmon
May 19, 2006·Journal of Neurophysiology·Brian HalabiskyDavid A Prince
May 23, 2006·Trends in Neurosciences·Adam M SillitoHelen E Jones
Nov 24, 2006·PLoS Biology·Ingrid BureauKarel Svoboda
Jan 24, 2007·Proceedings of the National Academy of Sciences of the United States of America·Ian M AndolinaAdam M Sillito
Sep 15, 2007·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Juan Torres-Reveron, Michael J Friedlander
Jun 24, 2008·Nature Reviews. Neuroscience·UNKNOWN Petilla Interneuron Nomenclature GroupRafael Yuste
Nov 5, 2008·Frontiers in Neuroscience·Rachel Aronoff, Carl C H Petersen
Dec 10, 2008·The Journal of Comparative Neurology·Chia-Chien ChenJoshua C Brumberg
Jan 29, 2009·Human Reproduction Update·M HickeyM Friedlander
Feb 20, 2009·Frontiers in Neuroscience·Andreas Burkhalter

❮ Previous
Next ❯

Citations

Oct 10, 2015·Cell·Henry MarkramFelix Schürmann
Oct 7, 2015·Frontiers in Neuroanatomy·Paul D WhissellJun Chul Kim
May 26, 2015·Frontiers in Neural Circuits·Mérie NassarDesdemona Fricker
Jul 11, 2014·Frontiers in Neuroanatomy·Bruno CauliJochen F Staiger
Jan 13, 2018·Frontiers in Neural Circuits·Scott RichVictoria Booth
Aug 17, 2019·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·Michael B KrawchukAlberto L Vazquez
Aug 21, 2020·Physiological Reviews·Jochen F Staiger, Carl C H Petersen
Mar 6, 2021·PeerJ·Thomas F Burns, Ramesh Rajan
Feb 24, 2021·Nature Neuroscience·Manuel ValeroGyörgy Buzsáki
Nov 14, 2020·Nature·Federico ScalaAndreas S Tolias

❮ Previous
Next ❯

Related Concepts

Related Feeds

Barrel cortex

Here is the latest research on barrel cortex, a region of somatosensory and motor corticies in the brain, which are used by animals that rely on whiskers for world exploration.

Related Papers

The Journal of Neuroscience : the Official Journal of the Society for Neuroscience
Anastassios KaragiannisBruno Cauli
Proceedings of the National Academy of Sciences of the United States of America
Bruno CauliE Audinat
© 2022 Meta ULC. All rights reserved