Diversity of Histologic Patterns and Expression of Cytoskeletal Proteins in Canine Skeletal Osteosarcoma

Veterinary Pathology
E NagamineH Taniyama

Abstract

Osteosarcoma (OS), the most common bone tumor, includes OS of the head (OSH) and appendicular OS (OSA). In dogs, it is classified into 6 histologic subtypes: osteoblastic, chondroblastic, fibroblastic, telangiectatic, giant cell, and poorly differentiated. This study investigated the significance of the histologic classification relevant to clinical outcome and the histologic and immunohistochemical relationships between pleomorphism and expression of cytoskeletal proteins in 60 cases each of OSH and OSA. Most neoplasms exhibited histologic diversity, and 64% of OS contained multiple subtypes. In addition to the above 6 subtypes, myxoid, round cell, and epithelioid subtypes were observed. Although the epithelioid subtypes were observed in only OSH, no significant difference in the frequency of other subtypes was observed. Also, no significant relevance was observed between the clinical outcome and histologic subtypes. Cytokeratin (CK) was expressed in both epithelioid and sarcomatoid tumor cells in various subtypes, and all CK-positive tumor cells also expressed vimentin. Vimentin and α-smooth muscle actin (SMA) were expressed in all subtypes. A few SMA-positive spindle-shaped tumor cells exhibited desmin expression. Glial fibr...Continue Reading

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Citations

Mar 2, 2016·Veterinary Pathology·A S Wehrle-MartinezK G Thompson
Aug 21, 2015·Veterinary Pathology·D E GunsonK E Gropp
Aug 16, 2017·Veterinary Pathology·Elise E B LaDouceurChristopher M Reilly
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Oct 27, 2017·Acta Veterinaria Scandinavica·Siobhan SimpsonCatrin Sian Rutland
Aug 2, 2018·Molecular Biology Reports·Camila Barbosa AmaralAna Maria Reis Ferreira
Sep 20, 2018·Veterinary Pathology·Jeff L CaswellJyoji Yamate
Jun 1, 2016·Veterinary Sciences·Florian R L Meyer, Ingrid Walter

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Methods Mentioned

BETA
amputation
biopsy
SMA

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