Diversity of MHC class I genes in Burmese-origin rhesus macaques.

Immunogenetics
Taeko NaruseAkinori Kimura

Abstract

Rhesus macaques (Macaca mulatta) are widely used in developing a strategy for vaccination against human immunodeficiency virus by using simian immunodeficiency virus infection as a model system. Because the genome diversity of major histocompatibility complex (MHC) is well known to control the immune responsiveness to foreign antigens, MHC loci in Indian- and Chinese-origin macaques used in the experiments have been characterized, and it was revealed that the diversity of MHC in macaques was larger than the human MHC. To further characterize the diversity of Mamu-A and Mamu-B loci, we investigated a total of 73 different sequences of Mamu-A, 83 sequences of Mamu-B, and 15 sequences of Mamu-I cDNAs isolated from Burmese-origin macaques. It was found that there were one to five expressing genes in each locus. Among the Mamu-A, Mamu-B, and Mamu-I sequences, 44 (60.2%), 45 (54.2%), and 8 (53.3%), respectively, were novel, and most of the other known alleles were identical to those reported from Chinese- or Indian-origin macaques, demonstrating a genetic mixture between the geographically distinct populations of present day China and India. In addition, it was found that a Mamu haplotype contained at least two highly transcribed Mam...Continue Reading

References

Aug 26, 1998·Current Biology : CB·C B Stewart, T R Disotell
Jan 21, 2000·The Journal of Immunology : Official Journal of the American Association of Immunologists·J A UrvaterD I Watkins
Nov 22, 2000·The Journal of Immunology : Official Journal of the American Association of Immunologists·J SidneyA Sette
Jan 10, 2003·Nucleic Acids Research·James RobinsonSteven G E Marsh
Feb 18, 2004·Nature Medicine·Thomas C FriedrichDavid I Watkins
Jun 24, 2004·The Journal of Experimental Medicine·Tetsuro MatanoYoshiyuki Nagai
Aug 4, 2004·Genome Research·Riza Daza-VamentaDaniel E Geraghty
Jan 25, 2005·Proceedings of the National Academy of Sciences of the United States of America·Nel OttingRonald E Bontrop
Jan 5, 2007·The Journal of Immunology : Official Journal of the American Association of Immunologists·Fuliang ChuGeorge F Gao
Mar 6, 2007·Immunogenetics·Nel OttingRonald E Bontrop
Apr 14, 2007·Science·UNKNOWN Rhesus Macaque Genome Sequencing and Analysis ConsortiumAnn S Zwieg
Jun 1, 2007·Journal of Virology·John T LoffredoDavid I Watkins
Dec 22, 2007·Immunogenetics·Julie A KarlDavid H O'Connor
Jul 12, 2008·Nature Reviews. Immunology·Philip J R Goulder, David I Watkins
Oct 8, 2008·The Journal of Experimental Medicine·Matthew R ReynoldsDavid I Watkins
Dec 25, 2008·Immunogenetics·Kevin J CampbellDavid H O'Connor
Feb 13, 2010·Immunogenetics·Cornelia RosnerLutz Walter

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Citations

Jul 7, 2011·Immunogenetics·Jason S ReedNancy A Wilson
Jan 29, 2014·Immunogenetics·Taeko K NaruseAkinori Kimura
May 10, 2011·Immunogenetics·Taeko K NaruseAkinori Kimura
Sep 2, 2011·Immunogenetics·Yusuke SaitoAkinori Kimura
Sep 21, 2013·Immunogenetics·Xiang YanZhaozeng Sun
Oct 30, 2015·Expert Review of Vaccines·Sayuri Seki, Tetsuro Matano
Jun 29, 2011·European Journal of Immunology·Jeroen H BlokhuisRonald E Bontrop
Aug 14, 2012·Microbes and Infection·Kyoko KuriharaTetsuro Matano
Feb 3, 2018·Annual Review of Immunology·Peter Parham, Lisbeth A Guethlein
Oct 13, 2017·The Journal of Immunology : Official Journal of the American Association of Immunologists·Natasja G de GrootRonald E Bontrop
Feb 27, 2018·Immunogenetics·Marit K H van der WielR E Bontrop
Dec 14, 2018·Proceedings of the Japan Academy. Series B, Physical and Biological Sciences·Taeko K NaruseAkinori Kimura
Nov 17, 2012·Nature Reviews. Microbiology·Theodora Hatziioannou, David T Evans
May 23, 2013·G3 : Genes - Genomes - Genetics·Julie A KarlDavid H O'Connor
Nov 12, 2015·Frontiers in Immunology·Lutz Walter, Aftab A Ansari
Apr 2, 2021·Neuroscience Letters·Susmita SilShilpa Buch
Apr 3, 2021·Infection, Genetics and Evolution : Journal of Molecular Epidemiology and Evolutionary Genetics in Infectious Diseases·Hla Myat MonHiroshi Tachibana

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