Diversity of sickle cell trait in Jharkhand state in India: Is it the zone of contact between two geographically and ethnically distinct populations in India?

Journal of Biosciences
Rachana Nagar, Rajiva Raman

Abstract

Incidence of sickle cell trait in India is high in peninsular south, south-eastern, central and south-western India, while in north and north-eastern India, it is absent. Unicentric origin of SCD in the tribals of nilgiri hills in southern India has been proposed. The present study on the frequency of HbS trait and beta-globin gene haplotypes was conducted in the tribal-rich states of Chhattisgarh and Jharkhand to get an insight into the uneven distribution of HbS in India. Jharkhand borders with the HbS-high Odisha and Chhattisgarh, and HbS-low UP, Bihar and Bengal. Cellulose acetate gel electrophoresis was performed on the collected blood samples, to detect sickle haemoglobin (HbS) followed by DNA analysis. HbS associated beta-gene haplotype was constructed for the samples positive for HbS and all the tribals by PCR-RFLP. Out of 805 (Chhattisgarh - 261, Jharkhand - 544; greater than 36 percent tribals) samples analysed HbS frequency was 13 percent in Chhattisgarh and 3.3 percent in Jharkhand. Within Jharkhand, frequencies varied considerably from 10 percent in Tatanagar to nil in Sahibganj. The Arab-India (AI) haplotype of beta-globin cluster occurred in low frequency, confined mainly to Chhattisgarh. The most abundant haplot...Continue Reading

References

Jun 1, 1997·American Journal of Hematology·M B MukherjeeR Krishnamoorthy
Jun 29, 2000·Baillière's Clinical Haematology·J FlintJ B Clegg
Aug 13, 2002·Journal of Korean Medical Science·Young-Joon LeeHan-Ik Cho
Jun 9, 2004·Hemoglobin·Malay B MukherjeeDipika Mohanty
Dec 1, 2007·The Clinical Respiratory Journal·Anne Marie McLaughlinRory A O'Donnell
Nov 24, 2011·Journal of Community Genetics·Pradeep K PatraGraham R Serjeant
Jul 26, 2014·Journal of Community Genetics·Rachana NagarRajiva Raman

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