Diversity of single potassium channels in isolated snail neurons

Neuroreport
A V SotkisE A Lukyanetz

Abstract

Comparison of K+ channels in mollusk and mammalian neurons has been made to elucidate their fundamental properties. Using patch clamp cell-attached configuration, K+ channels in isolated snail neurons were separated into three subtypes: with big (BKC), medium (MKC) and small (SKC) unitary conductances. BKC and MKC were activated at -30 mV and SKC at more negative potentials. BKC and MKC proved sensitive to TEA, whereas SKC were sensitive to 4-AP. Cd2+ in the pipet decreased unitary conductance of BKC by 55% and of MKC by about 31%. Bath application of 5-HT selectively suppressed MKC. It is suggested that BKC can be referred to large conductance Ca(2+)-dependent K+ currents (KCa), MKC to intermediate conductance KCa and SKC channels comply with the characteristics of A current of mammals. These data show that KCa and A currents may be the most general types of currents generated by K+ channels.

References

Feb 1, 1977·The Journal of Physiology·S H Thompson
Oct 1, 1987·The Journal of General Physiology·M J Shuster, S A Siegelbaum
Jan 1, 1988·Trends in Pharmacological Sciences·N S Cook
Jul 1, 1971·The Journal of General Physiology·E Neher
Dec 1, 1983·Cell Calcium·A Hermann, K Hartung
Jan 1, 1980·Annual Review of Neuroscience·D J AdamsS H Thompson
Dec 15, 1980·The Journal of Membrane Biology·H Reuter, C F Stevens
Mar 1, 1981·Pflügers Archiv : European journal of physiology·H D LuxA Marty
Aug 1, 1995·Diabetes Research and Clinical Practice·G Edwards, A H Weston
Jun 1, 1996·Pflügers Archiv : European journal of physiology·E A Lukyanetz, P G Kostyuk
Dec 1, 1995·Clinical and Experimental Pharmacology & Physiology·M J Christie

❮ Previous
Next ❯

Citations

Jun 11, 2002·Biochemical and Biophysical Research Communications·E A LukyanetzP G Kostyuk
Jul 9, 2011·Comparative Biochemistry and Physiology. Part A, Molecular & Integrative Physiology·Sodikdjon A Kodirov

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.