Diversity of vertebrate nicotinic acetylcholine receptors

Neuropharmacology
Neil S Millar, Cecilia Gotti

Abstract

Nicotinic acetylcholine receptors (nAChRs) are pentameric neurotransmitter receptors. They are members of the Cys-loop family of ligand-gated ion channels which also include ionotropic receptors for 5-hydroxytryptamine (5-HT), gamma-aminobutyric acid (GABA) and glycine. Nicotinic receptors are expressed in both the nervous system and at the neuromuscular junction and have been implicated in several neurological and neuromuscular disorders. In vertebrates, seventeen nAChR subunits have been identified (alpha1-alpha10, beta1-beta4, gamma, delta and epsilon) which can co-assemble to generate a diverse family of nAChR subtypes. This review will focus on vertebrate nAChRs and will provide an overview of the extent of nAChR diversity based on studies of both native and recombinant nAChRs.

References

Mar 1, 1990·Trends in Neurosciences·S N Abramson, P Taylor
Apr 1, 1991·Protein Expression and Purification·S W RogersS Heinemann
Mar 1, 1990·Proceedings of the National Academy of Sciences of the United States of America·R KullbergP Brehm
Nov 1, 1987·Proceedings of the National Academy of Sciences of the United States of America·J BoulterJ Patrick
Dec 11, 1974·Biochemical and Biophysical Research Communications·C L WeillA Karlin
Jun 1, 1995·Trends in Neurosciences·W N Green, N S Millar
May 19, 1995·The Journal of Biological Chemistry·P J CorringerD Bertrand
Oct 15, 1993·Proceedings of the National Academy of Sciences of the United States of America·S M Sine
Jul 26, 1996·The Journal of Biological Chemistry·F WangJ Lindstrom
Dec 24, 1997·Brain Research. Brain Research Reviews·H R Arias
May 29, 1998·Journal of Neurochemistry·S T Cooper, N S Millar
Jun 23, 1998·The Journal of Biological Chemistry·P J Groot-KormelinkL G Sivilotti
Jun 22, 1999·The Journal of Biological Chemistry·E PalmaM Ballivet
Jul 1, 1999·Molecular Pharmacology·S VailatiC Gotti
Apr 12, 2000·Progress in Neurobiology·D Paterson, A Nordberg
Apr 13, 2000·Pharmacology & Therapeutics·K Kawashima, T Fujii

❮ Previous
Next ❯

Citations

Aug 13, 2009·Journal of Molecular Neuroscience : MN·Michael J MarksAllan C Collins
Jul 9, 2013·Biochemical Pharmacology·Sara Francesca ColomboCecilia Gotti
Jul 17, 2013·Biochemical Pharmacology·Rogier B Poorthuis, Huibert D Mansvelder
Oct 29, 2013·European Journal of Pharmacology·Roger L PapkeM Imad Damaj
Sep 21, 2010·Quarterly Reviews of Biophysics·Andrew J ThompsonSarah C R Lummis
Jun 22, 2012·Journal of the American Chemical Society·Ximena Da Silva TavaresDennis A Dougherty
May 13, 2009·Acta Pharmacologica Sinica·Andon Nicholas PlaczekJohn Anthony Dani
Jun 6, 2009·Acta Pharmacologica Sinica·Ke-chun YangJie Wu
Jun 6, 2009·Acta Pharmacologica Sinica·Jie Wu
Mar 26, 2011·Proceedings of the National Academy of Sciences of the United States of America·Jaskiran K GillNeil S Millar
Feb 23, 2013·Proceedings of the National Academy of Sciences of the United States of America·Magali RichardJean-Louis Bessereau
Sep 14, 2013·The Journal of Biological Chemistry·Jane E CarlandJeremy J Lambert
Aug 27, 2010·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Layla AzamJ Michael McIntosh
Apr 20, 2010·Behavioural Pharmacology·Justin W KenneyThomas J Gould
Sep 18, 2012·Cold Spring Harbor Perspectives in Medicine·Natalia A Goriounova, Huibert D Mansvelder
Jan 27, 2010·The Journal of Pharmacology and Experimental Therapeutics·Roger L PapkeJerry A Stitzel
Jun 15, 2011·The Journal of Pharmacology and Experimental Therapeutics·Luping Z HuangMaryka Quik
Dec 7, 2011·The Journal of Pharmacology and Experimental Therapeutics·Tanuja BordiaMaryka Quik
Nov 2, 2012·The Journal of Pharmacology and Experimental Therapeutics·Kelen FreitasM Imad Damaj
Oct 5, 2011·Pharmacological Reviews·Maryka Quik, Susan Wonnacott
Aug 28, 2012·American Journal of Physiology. Lung Cellular and Molecular Physiology·Xiao Wen FuEliot R Spindel
May 8, 2010·American Journal of Respiratory Cell and Molecular Biology·Xiao Wen FuEliot R Spindel
Sep 15, 2010·PLoS Pathogens·Lucien RufenerDaniel Nilsson
Dec 4, 2013·Proceedings of the National Academy of Sciences of the United States of America·Natalia AndersenCecilia Bouzat
Feb 11, 2014·Neurological Sciences : Official Journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology·Cheng-Long XieZhen-Guo Liu
Jan 18, 2012·Psychopharmacology·Renata dos Santos Coura, Sylvie Granon
Dec 18, 2014·International Journal for Parasitology. Drugs and Drug Resistance·Timothy LynaghBodo Laube

❮ Previous
Next ❯

Related Concepts

Related Feeds

Amygdala and Midbrain Dopamine

The midbrain dopamine system is widely studied for its involvement in emotional and motivational behavior. Some of these neurons receive information from the amygdala and project throughout the cortex. When the circuit and transmission of dopamine is disrupted symptoms may present. Here is the latest research on the amygdala and midbrain dopamine.

Basal Ganglia

Basal Ganglia are a group of subcortical nuclei in the brain associated with control of voluntary motor movements, procedural and habit learning, emotion, and cognition. Here is the latest research.

Barrel cortex

Here is the latest research on barrel cortex, a region of somatosensory and motor corticies in the brain, which are used by animals that rely on whiskers for world exploration.