Diversity of vir Genes in Plasmodium vivax from Endemic Regions in the Republic of Korea: an Initial Evaluation

The Korean Journal of Parasitology
Ui-Han SonYoun-Kyoung Goo

Abstract

Variant surface antigens (VSAs) encoded by pir families are considered to be the key proteins used by many Plasmodium spp. to escape the host immune system by antigenic variation. This attribute of VSAs is a critical issue in the development of a novel vaccine. In this regard, a population genetic study of vir genes from Plasmodium vivax was performed in the Republic of Korea (ROK). Eighty-five venous blood samples and 4 of the vir genes, namely vir 27, vir 21, vir 12, and vir 4, were selected for study. The number of segregating sites (S), number of haplotypes (H), haplotype diversity (Hd), DNA diversity (π and Θw), and Tajima's D test value were conducted. Phylogenetic trees of each gene were constructed. The vir 21 (S=143, H=22, Hd=0.827) was the most genetically diverse gene, and the vir 4 (S=6, H=4, Hd=0.556) was the opposite one. Tajima's D values for vir 27 (1.08530, P>0.1), vir 12 (2.89007, P<0.01), and vir 21 (0.40782, P>0.1) were positive, and that of vir 4 (-1.32162, P>0.1) was negative. All phylogenetic trees showed 2 clades with no particular branching according to the geographical differences and cluster. This study is the first survey on the vir genes in ROK, providing information on the genetic level. The sample...Continue Reading

References

Apr 1, 1975·Theoretical Population Biology·G A Watterson
Nov 18, 1989·Lancet·K H RieckmannD C Hutton
Sep 1, 1995·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·A MurrayA Moore
Oct 1, 1993·Molecular and Biochemical Parasitology·G SnounouK N Brown
Dec 1, 1996·Tropical Medicine & International Health : TM & IH·V K DuaV P Sharma
Oct 28, 2004·Nucleic Acids Research·Christoph S JanssenMichael P Barrett
Dec 8, 2004·International Journal for Parasitology·Hernando A del PortilloCarmen Fernandez-Becerra
Oct 22, 2005·Molecular Microbiology·Carmen Fernandez-BecerraHernando A del Portillo
Jul 11, 2007·Indian Pediatrics·Rajoo ThapaRitabrata Kundu
Nov 28, 2008·Trends in Parasitology·Carmen Fernandez-BecerraHernando A del Portillo
Jan 20, 2009·The International Journal of Biochemistry & Cell Biology·Noa D Pasternak, Ron Dzikowski
Aug 22, 2009·The Lancet Infectious Diseases·Ivo MuellerHernando A del Portillo
Dec 17, 2009·Human Vaccines·Myriam Arévalo-HerreraSócrates Herrera
Jul 14, 2010·The Journal of Infectious Diseases·Bruna O CarvalhoFabio T M Costa
Jan 18, 2013·BMC Genomics·Francisco Javier LopezHernando A del Portillo
Oct 30, 2014·The Korean Journal of Parasitology·Purva GuptaVineeta Singh
Jun 14, 2015·BMC Medicine·Ursula DalrymplePeter W Gething
Jul 2, 2015·Malaria Journal·Arletta AñezCarlos Ascaso
Sep 24, 2015·Antimicrobial Agents and Chemotherapy·Pham Vinh ThanhAnnette Erhart
Nov 28, 2015·Trends in Molecular Medicine·Jean Popovici, Didier Ménard
Feb 16, 2016·Infection, Genetics and Evolution : Journal of Molecular Epidemiology and Evolutionary Genetics in Infectious Diseases·Purva GuptaVineeta Singh
Mar 24, 2016·Molecular Biology and Evolution·Sudhir KumarKoichiro Tamura
Mar 26, 2016·Molecular and Biochemical Parasitology·Andrew P Jackson

❮ Previous
Next ❯

Citations

Jan 30, 2018·Pathogens and Global Health·Stephanie Tannous, Esther Ghanem
Jan 12, 2019·The Korean Journal of Parasitology·Young Yil BahkTong-Soo Kim
Nov 10, 2020·Heliyon·Adriana HigueraJuan David Ramírez
Nov 5, 2020·Parasitology International·Byoung-Kuk NaYoun-Kyoung Goo

❮ Previous
Next ❯

Methods Mentioned

BETA
PCR

Software Mentioned

DnaSP
MEGA
BioEdit
Clustal Omega
BLAST

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.